2-MAG is hydrolyzed to fatty acid and glycerol by MGLL

Stable Identifier
R-HSA-1482543
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
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At the endoplasmic reticulum (ER) membrane, monoglyceride lipase (MGLL) hydrolyzes 2-monoacylglycerol (2-MAG) to form a fatty acid and glycerol (Dinh et al. 2004, Zvonok et al. 2008, Bertrand et al. 2010, Labar et al. 2010).
Literature References
PubMed ID Title Journal Year
15272052 RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol

Kathuria, S, Dinh, TP, Piomelli, D

Mol Pharmacol 2004
19962385 Structural basis for human monoglyceride lipase inhibition

Berne, PF, Rak, A, Houtmann, J, Bertrand, T, Mathieu, M, Augé, F, Mikol, V, Hoornaert, C, Cheuret, D, Vallée, F, Michot, N

J Mol Biol 2010
18452279 Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification

Williams, J, Krishnan, SC, Johnston, M, Janero, DR, Li, J, Zvonok, N, Pandarinathan, L, Makriyannis, A

J Proteome Res 2008
19957260 Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling

Borel, F, Labar, G, Wouters, J, Bauvois, C, Lambert, DM, Ferrer, JL

Chembiochem 2010
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Catalyst Activity

monoacylglycerol lipase activity of MGLL dimer [endoplasmic reticulum membrane]

Physical Entity
MGLL dimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monoacylglycerol lipase activity (GO:0047372)
Orthologous Events
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Gallus gallus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Saccharomyces cerevisiae)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Schizosaccharomyces pombe)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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