2-acyl LPC is acylated to PC by LPCAT

Stable Identifier
Reaction [transition]
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylcholine (LPC) to form phosphatidylcholine (PC). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006); lysophosphatidylcholine acyltransferase 2 (LPCAT2) (Shindou et al. 2006); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008).
Literature References
PubMed ID Title Journal Year
18772128 Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils

Zarini, S, Voelker, DR, Riekhof, WR, Gijon, MA, Murphy, RC

J Biol Chem 2008
16243729 Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7

Chen, C, Wan, B, Huang, S, Ye, GM, Guo, JH, Han, DD, Yu, L

DNA Seq 2005
18195019 Identification and characterization of a major liver lysophosphatidylcholine acyltransferase

Bensch, WR, Li, S, Cao, G, Bonacci, TM, Moller, DE, Bredt, DS, Kowala, M, Chen, YQ, Zhao, Y, Konrad, RJ

J Biol Chem 2008
16704971 Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production

Shindou, H, Suwabe, A, Ogasawara, R, Nakanishi, H, Taguchi, R, Shimizu, T, Harayama, T, Hishikawa, D

J Biol Chem 2006
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Revett, T, Tobin, JF, Cao, J, Li, D, Shan, D, Gimeno, RE, Wu, L, Liu, W

J Biol Chem 2008
16864775 Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells

Chen, X, Mucenski, ML, Mason, RJ, Hyatt, BA, Shannon, JM

Proc Natl Acad Sci U S A 2006
17182612 A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase

Shindou, H, Ishii, S, Nakanishi, H, Taguchi, R, Shimizu, T, Harayama, T, Hishikawa, D

J Biol Chem 2007
Catalyst Activity

2-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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