2-acyl LPC is acylated to PC by LPCAT

Stable Identifier
R-HSA-1482533
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylcholine (LPC) to form phosphatidylcholine (PC). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006); lysophosphatidylcholine acyltransferase 2 (LPCAT2) (Shindou et al. 2006); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References
PubMed ID Title Journal Year
16243729 Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7

Ye, GM, Chen, C, Huang, S, Han, DD, Guo, JH, Wan, B, Yu, L

DNA Seq 2005
18772128 Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils

Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR

J Biol Chem 2008
18195019 Identification and characterization of a major liver lysophosphatidylcholine acyltransferase

Zhao, Y, Chen, YQ, Bonacci, TM, Bredt, DS, Li, S, Bensch, WR, Moller, DE, Kowala, M, Konrad, RJ, Cao, G

J Biol Chem 2008
16704971 Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production

Nakanishi, H, Shindou, H, Hishikawa, D, Harayama, T, Ogasawara, R, Suwabe, A, Taguchi, R, Shimizu, T

J Biol Chem 2006
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE

J Biol Chem 2008
16864775 Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells

Chen, X, Hyatt, BA, Mucenski, ML, Mason, RJ, Shannon, JM

Proc Natl Acad Sci U S A 2006
17182612 A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase

Shindou, H, Hishikawa, D, Nakanishi, H, Harayama, T, Ishii, S, Taguchi, R, Shimizu, T

J Biol Chem 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
2-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created