Reactome | IGHA2 [extracellular region]

IGHA2 [extracellular region]

Stable Identifier

R-HSA-1478812

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Ig alpha-2 chain C region, IGHA2_HUMAN

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - FCAMR binds IgA (Homo sapiens)
    - 2xIgA:JCHAIN [extracellular region] (Homo sapiens)
      - IgA [extracellular region] (Homo sapiens)
        
        IgA Heavy Chain [extracellular region] (Homo sapiens)
        
        Ig alpha C region [extracellular region] (Homo sapiens)
        
        IGHA2 [extracellular region] (Homo sapiens)
    - FCAMR:2xIgA:JCHAIN [plasma membrane] (Homo sapiens)
      - 2xIgA:JCHAIN [extracellular region] (Homo sapiens)
        
        IgA [extracellular region] (Homo sapiens)
        
        IgA Heavy Chain [extracellular region] (Homo sapiens)
        
        Ig alpha C region [extracellular region] (Homo sapiens)
        
        IGHA2 [extracellular region] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging of heme from plasma (Homo sapiens)
    - Alpha-1-Microglobulin is cleaved (Homo sapiens)
      - 2xIgA:JCHAIN [extracellular region] (Homo sapiens)
        
        IgA [extracellular region] (Homo sapiens)
        
        IgA Heavy Chain [extracellular region] (Homo sapiens)
        
        Ig alpha C region [extracellular region] (Homo sapiens)
        
        IGHA2 [extracellular region] (Homo sapiens)
      - IgA:Alpha-1-Microglobulin [extracellular region] (Homo sapiens)
        
        2xIgA:JCHAIN [extracellular region] (Homo sapiens)
        
        IgA [extracellular region] (Homo sapiens)
        
        IgA Heavy Chain [extracellular region] (Homo sapiens)
        
        Ig alpha C region [extracellular region] (Homo sapiens)
        
        IGHA2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01877 IGHA2

Gene Names

IGHA2

Chain

chain:1-391

Reference Genes

ENSEMBL:ENSG00000211890 IGHA2

HGNC:5479 IGHA2

OMIM:147000 IGHA2

UCSC:P01877 IGHA2

Other Identifiers

11761899_a_at

11762091_x_at

11762099_x_at

11763249_x_at

11764130_s_at

16797336

16797368

215118_PM_s_at

215118_s_at

217022_3p_s_at

217022_PM_s_at

217022_s_at

33499_s_at

33500_i_at

33501_r_at

33613_at

3581638

3581639

3581640

3581641

3581642

3581643

3581644

3581645

3581646

3581647

3581648

3581649

3581650

3581777

3581778

3581781

3581783

57235_s_at

A_23_P61042

A_24_P169873

GO:0002250

GO:0002376

GO:0003014

GO:0003094

GO:0003823

GO:0005576

GO:0005615

GO:0005886

GO:0006955

GO:0006958

GO:0019731

GO:0019814

GO:0034987

GO:0042571

GO:0043226

GO:0050853

GO:0060267

GO:0070062

GO:0071745

GO:0071748

GO:0071751

GO:0071752

GO:0072562

GO:0098542

HMNXSV003019957

Hs.163271.0.S1_3p_s_at

Hs.293441.3.A1_3p_a_at

Hs.293441.3.A1_3p_s_at

S71043_rna1_s_at

TC14002210.hg

p4715

Participates

as a member of

Ig alpha C region [extracellular region] (Homo sapiens)

Inferred To

IGHA2 [extracellular region] (Bos taurus)

IGHA2 [extracellular region] (Canis familiaris)

Igha [extracellular region] (Mus musculus)

Homologues of IGHA2 [extracellular region] (Canis familiaris)

Cross References

ENSEMBL

ENST00000497872, ENSP00000493086, ENST00000390539, ENSP00000374981

OpenTargets

ENSG00000211890

HPA

ENSG00000211890-IGHA2

PRO

P01877

GlyGen

P01877

PDB

6UE9, 6UE8, 6UEA, 3CM9

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	2
UniProt:O14949 UQCRQ	1	UQCRQ [mitochondrial inner membrane] (R-HSA-164283)	0.527	2
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.527	2
UniProt:Q9GZQ4 NMUR2	1	NMUR2 [plasma membrane] (R-HSA-964816)	0.527	2