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IGHE [extracellular region]
Stable Identifier
R-HSA-1478806
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Ig epsilon chain C region, IGHE_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT6-upregulated extracellular proteins (Homo sapiens)
STAT6 upregulated extracellular proteins [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Allergen dependent IgE bound FCERI aggregation (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of SHC by SYK kinase (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Phosphorylation of PKC-theta (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
IgE binds FCERI (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
IgE binds omalizumab (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
IgE:omalizumab [extracellular region] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
SYK/FYN [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE Heavy Chain [extracellular region] (Homo sapiens)
IGHE [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01854 IGHE
Gene Names
IGHE
Chain
chain:1-546
Reference Genes
ENSEMBL:ENSG00000211891 IGHE
HGNC:5522 IGHE
OMIM:147180 IGHE
UCSC:P01854 IGHE
Other Identifiers
1558437_PM_at
1558438_PM_a_at
1558438_a_at
16797340
217469_PM_at
217469_at
234373_3p_x_at
234373_PM_x_at
234373_x_at
35601_at
3581665
3581666
3581667
3581670
3581671
3581672
3581673
3581674
3581675
3581676
3581677
3581678
3581803
3581804
3581805
3581810
3581811
3581812
3581814
7981708
A_24_P109921
A_33_P3340852
GO:0001788
GO:0002250
GO:0002376
GO:0002450
GO:0003823
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006954
GO:0006955
GO:0006958
GO:0016068
GO:0016192
GO:0019731
GO:0019814
GO:0030154
GO:0030225
GO:0034987
GO:0042092
GO:0042100
GO:0042116
GO:0042571
GO:0043303
GO:0043308
GO:0050853
GO:0071742
GO:0071744
GO:0098542
GO:0160006
HMNXSV003036379
HMNXSV003036530
HMNXSV003054405
Hs.247930.0.S1_3p_at
Hs.247930.0.S1_3p_s_at
Hs.247930.0.S1_3p_x_at
Hs.274600.0.S1_3p_at
Hs2.145288.1.A1_3p_at
Hs2.145288.1.A1_3p_s_at
Hs2.145288.1.A1_3p_x_at
L00022_s_at
M55420_at
TC14002212.hg
p4707
p4708
p4709
p4710
Participates
as a member of
STAT6 upregulated extracellular proteins [extracellular region] (Homo sapiens)
as a component of
IgE Heavy Chain [extracellular region] (Homo sapiens)
Inferred To
IGHE [extracellular region]
(Bos taurus)
IGHE [extracellular region]
(Canis familiaris)
IGHE [extracellular region]
(Mus musculus)
IGHE [extracellular region]
(Sus scrofa)
Ghost homologue of IGHE [extracellular region]
(Gallus gallus)
ENSRNOG00000070986 [extracellular region]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2741
OpenTargets
ENSG00000211891
ENSEMBL
ENSP00000481089
,
ENSP00000374983
,
ENSP00000492979
,
ENST00000641420
,
ENST00000390541
,
ENST00000610670
HPA
ENSG00000211891-IGHE
PRO
P01854
Pharos - Targets
P01854
GlyGen
P01854
PDB
2Y7Q
,
6EYO
,
7MXI
,
1O0V
,
5ANM
,
1G84
,
4J4P
,
6UQR
,
3H9Z
,
3H9Y
,
1F6A
,
4GKO
,
5MOI
,
4GRG
,
4GT7
,
7SHT
,
8C1B
,
4EZM
,
5MOJ
,
7SI0
,
3HA0
,
7SHU
,
8C1C
,
5LGK
,
5LGJ
,
2WQR
,
5HYS
,
5MOL
,
7SHY
,
7SHZ
,
5MOK
,
4KI1
,
1FP5
,
5NQW
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