Reactome | IGHE [extracellular region]

IGHE [extracellular region]

Stable Identifier

R-HSA-1478806

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Ig epsilon chain C region, IGHE_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - Expression of STAT6-upregulated extracellular proteins (Homo sapiens)
        
        STAT6 upregulated extracellular proteins [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - Allergen dependent IgE bound FCERI aggregation (Homo sapiens)
      - FCERI:IgE [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - FCERI mediated Ca+2 mobilization (Homo sapiens)
      - Phosphorylation of PLC-gamma (Homo sapiens)
        
        p-SYK/p-BTK [plasma membrane] (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Phosphorylation of SHC by SYK kinase (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - FCERI mediated NF-kB activation (Homo sapiens)
      - Phosphorylation of PKC-theta (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - IgE binds FCERI (Homo sapiens)
      - FCERI:IgE [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - IgE binds omalizumab (Homo sapiens)
      - IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - IgE:omalizumab [extracellular region] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - Phosphorylation of LAT by p-SYK (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - Phosphorylation of SYK (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
      - Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
        
        SYK/FYN [plasma membrane] (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)
      - Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        IgE [extracellular region] (Homo sapiens)
        
        IgE Heavy Chain [extracellular region] (Homo sapiens)
        
        IGHE [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01854 IGHE

Gene Names

IGHE

Chain

chain:1-546

Reference Genes

ENSEMBL:ENSG00000211891 IGHE

ENSEMBL_homo_sapiens_GENE:ENSG00000211891.6 IGHE

ENSEMBL_homo_sapiens_GENE:ENSG00000276192.2 IGHE

HGNC:5522 IGHE

OMIM:147180 IGHE

UCSC:P01854 IGHE

Other Identifiers

1558437_PM_at

1558438_PM_a_at

1558438_a_at

16797340

217469_PM_at

217469_at

35601_at

3581670

3581671

3581672

3581673

3581674

3581675

3581676

3581677

3581678

3581810

3581811

3581812

3581814

7981708

A_24_P109921

A_33_P3340852

GO:0002250

GO:0002376

GO:0003823

GO:0005576

GO:0005615

GO:0005886

GO:0006954

GO:0006955

GO:0006958

GO:0016020

GO:0019731

GO:0019814

GO:0023052

GO:0034987

GO:0042571

GO:0050853

GO:0071742

GO:0098542

HMNXSV003036379

HMNXSV003036530

HMNXSV003054405

Hs.274600.0.S1_3p_at

Hs2.145288.1.A1_3p_at

Hs2.145288.1.A1_3p_s_at

Hs2.145288.1.A1_3p_x_at

L00022_s_at

p4708

p4709

p4710

Participates

as a member of

STAT6 upregulated extracellular proteins [extracellular region] (Homo sapiens)

as a component of

IgE Heavy Chain [extracellular region] (Homo sapiens)

Inferred To

IGHE [extracellular region] (Bos taurus)

IGHE [extracellular region] (Canis familiaris)

IGHE [extracellular region] (Mus musculus)

IGHE [extracellular region] (Sus scrofa)

Ghost homologue of IGHE [extracellular region] (Gallus gallus)

ENSRNOG00000070986 [extracellular region] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2741

OpenTargets

ENSG00000211891

GeneCards

P01854

HPA

ENSG00000211891-IGHE

Ensembl

ENSG00000211891, ENST00000390541, ENSP00000481089, ENST00000610670, ENSP00000374983, ENSG00000276192

PRO

P01854

Pharos - Targets

P01854

PDB

1FP5, 5NQW, 5MOL, 2WQR, 6UQR, 5MOJ, 3H9Y, 3H9Z, 5MOK, 8C1B, 5MOI, 5ANM, 2Y7Q, 5LGJ, 8C1C, 5LGK, 7MXI, 4J4P, 4GT7, 7SHZ, 7SHY, 1G84, 4GRG, 7SI0, 1F6A, 4KI1, 4GKO, 7SHU, 3HA0, 6EYO, 5HYS, 7SHT, 1O0V, 4EZM

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