CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-

Stable Identifier
R-HSA-1475435
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Carbonic anhydrase I/II hydrates carbon dioxide
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Carbonic anhydrase I (CA1, Khalifah 1971, Pesando 1975, Simonsson et al. 1982, Ren & Lindskog 1992) and carbonic anhydrase II (CA2, Tibell et al. 1984, Jones & Shaw 1983, Ghannam et al. 1986) hydrate carbon dioxide (CO2) to yield bicarbonate (HCO3-) and a proton (H+). During the reaction a hydroxyl group bound by the zinc ion (Zn2+) attacks the CO2 molecule in the active site to directly form HCO3- (reviewed in Lindskog 1997). The HCO3- is displaced by water, which is then deprotonated by a histidine residue to recreate the Zn2+:hydroxyl group. Depending on the concentrations of reactants the reaction is reversible.
Participants
Participates
Event Information
Catalyst Activity

carbonate dehydratase activity of CA1:Zn2+,CA2:Zn2+ [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!