Reactome | Carbonic anhydrase dehydrates bicarbonate (mitochondria)

Carbonic anhydrase dehydrates bicarbonate (mitochondria)

Stable Identifier

R-HSA-1475028

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Carbonic anhydrase dehydrates bicarbonate (mitochondria)

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Carbonic anhydrase VA (CA5A, Nagao et al. 1993, Franchi et al. 2003, Nishimori et al. 2007) and carbonic anhydrase VB (CA5B, Fujikawa-Adachi et al. 1999, Nishimori et al. 2005, Nishimori et al. 2007) dehydrate bicarbonate in mitochondria to yield water and carbon dioxide (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.

Literature References

PubMed ID	Title	Journal	Year
10409679	Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x Fujikawa-Adachi, K, Nishimori, I, Taguchi, T, Onishi, S	J Biol Chem	1999
16302824	Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors Nishimori, I, Vullo, D, Innocenti, A, Scozzafava, A, Mastrolorenzo, A, Supuran, CT	J Med Chem	2005
8356065	Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16 Nagao, Y, Platero, JS, Waheed, A, Sly, WS	Proc Natl Acad Sci U S A	1993
17761422	Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different Nishimori, I, Innocenti, A, Vullo, D, Scozzafava, A, Supuran, CT	Bioorg Med Chem	2007
14611844	Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions Franchi, M, Vullo, D, Gallori, E, Antel, J, Wurl, M, Scozzafava, A, Supuran, CT	Bioorg Med Chem Lett	2003
9336012	Structure and mechanism of carbonic anhydrase Lindskog, S	Pharmacol Ther	1997