Collagen type II degradation by MMP14

Stable Identifier
R-HSA-1474196
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Collagen type II degradation by MMP14
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The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collagenase. MMP14 is able to degrade collagen types I, II and III (Ohuchi et al. 1997).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Collagen type II degradation by MMP14 (Homo sapiens)
Authored
Jupe, S  (2011-07-12)
Reviewed
Sorsa, T  (2012-10-08)
Created
Jupe, S  (2011-08-05)
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