Beta-defensins 1, 4A and 103 bind CCR6

Stable Identifier
R-HSA-1471338
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Beta-defensins 1, 4A and 103 bind CCR6
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The chemotactic activity of beta-defensins 1, 4A and 103 (hBD1-3) for immune and inflammatory cells such as memory T cells and immature dendritic cells is mediated through binding to the chemokine receptor CCR6.

Literature References
PubMed ID Title Journal Year
11934878 Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway

Nagaoka, I, Niyonsaba, F, Ogawa, H, Iwabuchi, K, Matsuda, H

Int Immunol 2002
10521347 Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

Howard, OM, Schröder, JM, Buffo, MJ, Chertov, O, Wang, JM, Oppenheim, JJ, Yang, D, Anderson, M, Shogan, J, Bykovskaia, SN, Chen, Q

Science 1999
10914484 Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Chertov, O, Oppenheim, JJ, Yang, D, Chen, Q

J Leukoc Biol 2000
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Orthologous Events
Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)
Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)
Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)
Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)
Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)
Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-08-03)
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