Beta-defensins 1, 4A and 103 bind CCR6

Stable Identifier
R-HSA-1471338
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Beta-defensins 1, 4A and 103 bind CCR6
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The chemotactic activity of beta-defensins 1, 4A and 103 (hBD1-3) for immune and inflammatory cells such as memory T cells and immature dendritic cells is mediated through binding to the chemokine receptor CCR6.
Literature References
PubMed ID Title Journal Year
11934878 Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway

Niyonsaba, F, Iwabuchi, K, Matsuda, H, Ogawa, H, Nagaoka, I

Int Immunol 2002
10521347 Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

Yang, D, Chertov, O, Bykovskaia, SN, Chen, Q, Buffo, MJ, Shogan, J, Anderson, M, Schröder, JM, Wang, JM, Howard, OM, Oppenheim, JJ

Science 1999
10914484 Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D, Chen, Q, Chertov, O, Oppenheim, JJ

J Leukoc Biol 2000
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Orthologous Events
Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)
Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)
Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)
Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)
Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)
Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-08-03)
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