Beta-defensins 1, 4A and 103 bind CCR6

Stable Identifier
R-HSA-1471338
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Beta-defensins 1, 4A and 103 bind CCR6
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The chemotactic activity of beta-defensins 1, 4A and 103 (hBD1-3) for immune and inflammatory cells such as memory T cells and immature dendritic cells is mediated through binding to the chemokine receptor CCR6.

Literature References
PubMed ID Title Journal Year
10521347 Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

Yang, D, Chertov, O, Bykovskaia, SN, Chen, Q, Buffo, MJ, Shogan, J, Anderson, M, Schröder, JM, Wang, JM, Howard, OM, Oppenheim, JJ

Science 1999
11934878 Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway

Niyonsaba, F, Iwabuchi, K, Matsuda, H, Ogawa, H, Nagaoka, I

Int Immunol 2002
10914484 Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D, Chen, Q, Chertov, O, Oppenheim, JJ

J Leukoc Biol 2000
Participants
Input
Output
Participant Of
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Orthologous Events
Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)
Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)
Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)
Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)
Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)
Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-08-03)