Reactome | Beta-defensins are secreted

Beta-defensins are secreted

Stable Identifier

R-HSA-1471322

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, extracellular region

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Beta defensin precursors are more simple in structure than those of alpha defensins, having a signal sequence, a short or absent propiece and the mature defensin sequence at the C-terminus. The signal sequence is cleaved off by a signal peptidase in the endoplasmic reticulum (Ganz 2003). Mature beta defensins 1, 2, 3, and 4 are secreted primarily by epithelial cells but are also produced by some immune cells such as monocytes, macrophages and dendritic cells (Duits et al. 2000, Ryan et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
9541493	Human beta-defensin-1: an antimicrobial peptide of urogenital tissues Valore, EV, Park, CH, Quayle, AJ, Wiles, KR, McCray PB, Jr, Ganz, T	J Clin Invest	1998
21122132	Tissue-specific human beta-defensins (HBD)1, HBD2, and HBD3 secretion from human extra-placental membranes stimulated with Escherichia coli Garcia-Lopez, G, Flores-Espinosa, P, Zaga-Clavellina, V	Reprod Biol Endocrinol	2010