Beta-defensins are secreted

Stable Identifier
R-HSA-1471322
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Beta defensin precursors are more simple in structure than those of alpha defensins, having a signal sequence, a short or absent propiece and the mature defensin sequence at the C-terminus. The signal sequence is cleaved off by a signal peptidase in the endoplasmic reticulum (Ganz 2003). Mature beta defensins 1, 2, 3, and 4 are secreted primarily by epithelial cells but are also produced by some immune cells such as monocytes, macrophages and dendritic cells (Duits et al. 2000, Ryan et al. 2003).

Literature References
PubMed ID Title Journal Year
9541493 Human beta-defensin-1: an antimicrobial peptide of urogenital tissues

Valore, EV, Park, CH, Quayle, AJ, Wiles, KR, McCray PB, Jr, Ganz, T

J Clin Invest 1998
21122132 Tissue-specific human beta-defensins (HBD)1, HBD2, and HBD3 secretion from human extra-placental membranes stimulated with Escherichia coli

Garcia-Lopez, G, Flores-Espinosa, P, Zaga-Clavellina, V

Reprod Biol Endocrinol 2010
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created