Beta defensin precursors are more simple in structure than those of alpha defensins, having a signal sequence, a short or absent propiece and the mature defensin sequence at the C-terminus. The signal sequence is cleaved off by a signal peptidase in the endoplasmic reticulum (Ganz 2003). Mature beta defensins 1, 2, 3, and 4 are secreted primarily by epithelial cells but are also produced by some immune cells such as monocytes, macrophages and dendritic cells (Duits et al. 2000, Ryan et al. 2003).
Valore, EV, Park, CH, Quayle, AJ, Wiles, KR, McCray PB, Jr, Ganz, T
Garcia-Lopez, G, Flores-Espinosa, P, Zaga-Clavellina, V
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