HNP1-3 bind CD4

Stable Identifier
R-HSA-1471314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Alpha-defensins, theta-defensins and their synthetic analogues the retrocyclins have been shown in numerous studies to have anti-HIV-1 activity (Chang & Klotman 2004). This appears to be mediated via multiple mechanisms including direct viral inactivation and down regulation of host-cell target co-receptors important for viral entry (Furci et al. 2007, Seidel et al. 2010). Further, HNPs 1 3, act as lectins and bind with relatively high affinity to gp120 (KD range, 15.8-52.8 nM) on the HIV-1 envelope and CD4 (KD range, 8.0-34.9 nM) on host target cells, both important molecules for viral entry (Wang et al. 2004). Artificial theta defensins, the retrocyclins, predicted from the human pseudogenes bind with even higher affinity whereas HNP-4 binding is much weaker (Wu et al. 2005). Alpha defensins have been demonstrated to inhibit the binding of gp120 to CD4 thus blocking HIV-1 fusion with its target cells (Furci et al. 2007).

Literature References
PubMed ID Title Journal Year
15210812 Activity of alpha- and theta-defensins against primary isolates of HIV-1

Wang, W, Owen, SM, Rudolph, DL, Cole, AM, Hong, T, Waring, AJ, Lal, RB, Lehrer, RI

J Immunol 2004
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