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Disassociation and translocation of STATs to the nucleus
Stable Identifier
R-HSA-1470012
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
nucleoplasm
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Disassociation and translocation of STATs to the nucleus (Homo sapiens)
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After dimerization STAT dimers release from the receptor complex and migrate to the nucleus for DNA binding. STAT5s/STAT1alpha heterodimeric complexes specifically recognize beta-casein promoter region (PIE) (Brizzi et al. 1999). c-Kit dependent JAK/STAT activation is associated with the growth and differentiation of fetal liver haematopoietic progenitor cells (Rönnstrand 2004, Reber et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
10358045
STAT protein recruitment and activation in c-Kit deletion mutants
Yarden, Y
,
Dentelli, P
,
Pegoraro, L
,
Rosso, A
,
Brizzi, MF
J Biol Chem
1999
Participants
Input
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane]
(Homo sapiens)
Output
p-JAK2:SFKs:p-KIT complex [plasma membrane]
(Homo sapiens)
p-STAT dimers [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Signaling by SCF-KIT (Homo sapiens)
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Disassociation and translocation of STATs to the nucleus (Mus musculus)
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Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)
Authored
Garapati, P V (2011-07-11)
Reviewed
Rönnstrand, L (2011-08-22)
Created
Garapati, P V (2011-08-01)
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