Downregulation of c-Kit signaling by SOCS6

Stable Identifier
R-HSA-1470011
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
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Downregulation of c-Kit signaling by SOCS6
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SOCS6 protein interacts with the phosphorylated Y568 in the juxtamembrane domain of c-Kit following SCF-stimulated tyrosine phosphorylation. Binding of SOCS6 to Y568 may mask this docking site for Src family kinases and this may inhibit the phosphorylation of p38 and ERK. This negatively regulates c-Kit receptor proliferation signal but not SCF-induced chemotaxis (Bayle et al. 2004, Zadjali et al 2011). Binding of SOCS6 mediates recruitment of elongin B and C to form a ubiquitin E3 ligase complex that leads to ubiquitination of KIT and its degradation (Zadjali et al 2011).

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Output
Participant Of
hasEvent
Inferred From
Downregulation of c-Kit signaling by Socs6 (Mus musculus)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-08-01)