Phosphorylation of STATs

Stable Identifier
R-HSA-1470009
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Phosphorylation of STATs
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JAK2 activation results in the phosphorylation and activation of STAT1alpha, STAT3, STAT5A and STAT5B (Deberry et al. 1997, Brizzi et al. 1999, Ning et al. 2001, Ronnstrand 2004). STAT family members can be activated by JAK kinases, receptor tyrosine kinases or SFKs. LYN kinase has been identified to have role in SCF-induced phosphorylation of STAT3 (Shivakrupa & Linnekin 2005).

Literature References
PubMed ID Title Journal Year
9355737 Stat1 associates with c-kit and is activated in response to stem cell factor

DeBerry, C, Mou, S, Linnekin, D

Biochem J 1997
10358045 STAT protein recruitment and activation in c-Kit deletion mutants

Brizzi, MF, Dentelli, P, Rosso, A, Yarden, Y, Pegoraro, L

J Biol Chem 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane]
Physical Entity
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of STATs (Bos taurus)
Phosphorylation of STATs (Canis familiaris)
Phosphorylation of STATs (Danio rerio)
Phosphorylation of STATs (Mus musculus)
Phosphorylation of STATs (Rattus norvegicus)
Phosphorylation of STATs (Sus scrofa)
Phosphorylation of STATs (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-08-01)