Reactome | Phosphorylation of STATs

Phosphorylation of STATs

Stable Identifier

R-HSA-1470009

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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JAK2 activation results in the phosphorylation and activation of STAT1alpha, STAT3, STAT5A and STAT5B (Deberry et al. 1997, Brizzi et al. 1999, Ning et al. 2001, Ronnstrand 2004). STAT family members can be activated by JAK kinases, receptor tyrosine kinases or SFKs. LYN kinase has been identified to have role in SCF-induced phosphorylation of STAT3 (Shivakrupa & Linnekin 2005).

Literature References

PubMed ID	Title	Journal	Year
10358045	STAT protein recruitment and activation in c-Kit deletion mutants Brizzi, MF, Dentelli, P, Rosso, A, Yarden, Y, Pegoraro, L	J Biol Chem	1999
9355737	Stat1 associates with c-kit and is activated in response to stem cell factor DeBerry, C, Mou, S, Linnekin, D	Biochem J	1997