Binding of defensins to lipid II

Stable Identifier
Homo sapiens
Related Species
Staphylococcus aureus
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In S. aureus, rather than cause gross membrane changes, HNP-1 (de Leeuw et al. 2010) and hBD3 (Sass et al. 2011) appear to interfere with cell wall biosynthetic pathways by binding to Lipid II (undecaprenylpyrophosphate-MurNAc[pentapeptide]-GlcNAc), an essential precursor of bacterial cell walls and the target of several antibiotics (Breukink & de Krujiff 2007). The transformation of monomeric lipid II into a polymeric peptidoglycan by the bifunctional S. aureus enzyme Penicillin-binding protein 2 (PBP2) is inhibited by hBD3 (Sass et al. 2011) resulting in local lesions of the cell wall layer through which membranes and cytoplasmic contents ultimately protrude.

Literature References
PubMed ID Title Journal Year
20214904 Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II

Breukink, E, Zeng, P, Li, C, Li, C, Lu, WY, Diepeveen-de Buin, M, Lu, W, de Leeuw, E

FEBS Lett 2010
20385753 Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci

Schneider, T, Novikova, N, Tossi, A, Wilmes, M, Shamova, O, Sahl, HG, K├Ârner, C, Sass, V

Infect Immun 2010
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