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GalNAc-MUC20 [Golgi lumen]
Stable Identifier
R-HSA-1463443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
Tn antigen (MUC20)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with O-glycosylation of proteins (Homo sapiens)
Defective C1GALT1C1 causes TNPS (Homo sapiens)
Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
Termination of O-glycan biosynthesis (Homo sapiens)
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC20 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N307 MUC20
Gene Names
MUC20, KIAA1359, UNQ2782/PRO7170
Chain
signal peptide:1-25, chain:26-709
Reference Genes
BioGPS Gene:200958 MUC20
COSMIC (genes):MUC20 MUC20
CTD Gene:200958 MUC20
dbSNP Gene:200958 MUC20
ENSEMBL:ENSG00000176945 MUC20
HGNC:23282 MUC20
KEGG:hsa:200958 MUC20
Monarch:200958 MUC20
NCBI Gene:200958 MUC20
OMIM:610360 MUC20
UCSC:Q8N307 MUC20
Reference Transcript
RefSeq:NM_001291833.1 MUC20
RefSeq:NM_001282506.1 MUC20
RefSeq:NM_152673.3 MUC20
RefSeq:NM_020790.1 MUC20
Other Identifiers
11727919_a_at
11739397_a_at
11758003_s_at
16949839
200958
230043_PM_at
230043_at
231941_PM_s_at
231941_s_at
243774_PM_at
243774_at
2659127
2659128
2659131
2659132
2659133
2659134
2659135
2659137
2659138
2659139
2659140
2659141
2659142
2659144
2659145
2659147
2659149
2659154
2659155
2659156
2659157
2659158
2659159
4052743
4052744
4052745
67709_at
8084895
81498_at
A_14_P135016
A_23_P92222
A_23_P92225
A_33_P3226775
GE53928
GO:0005576
GO:0005796
GO:0005886
GO:0009925
GO:0016323
GO:0016324
GO:0031528
GO:0042802
GO:0042995
GO:0048012
HMNXSV003019607
HMNXSV003027676
Hs.120845.0.A1_3p_at
Hs.299416.0.A1_3p_at
Hs.69321.0.A1_3p_x_at
ILMN_1653278
PH_hs_0004098
TC03003365.hg
p12197
p12198
p33558
p33559
Participates
as a member of
Tn antigens [Golgi lumen] (Homo sapiens)
Other forms of this molecule
MUC20 [plasma membrane]
GalNAc-MUC20 [plasma membrane]
Core 2 (MUC20) [Golgi lumen]
Core 2a (MUC20) [Golgi lumen]
Sialyl Tn antigen (MUC20) [Golgi lumen]
T-antigen (MUC20) [Golgi lumen]
Sialyl-2,3 T-antigen (MUC20) [Golgi lumen]
Sialyl T-antigen (MUC20) [Golgi lumen]
Disialyl T-antigen (MUC20) [Golgi lumen]
MUC20 [Golgi lumen]
Core 6 (MUC20) [Golgi lumen]
extended Core 6 (MUC20) [Golgi lumen]
Core 7 (MUC20) [Golgi lumen]
Core 3 (MUC20) [Golgi lumen]
Core 4 (MUC20) [Golgi lumen]
Core 5 (MUC20) [Golgi lumen]
Core 2S (MUC20) [Golgi lumen]
Core 8 (MUC20) [Golgi lumen]
Inferred To
Muc20 [Golgi lumen]
(Mus musculus)
Muc20 [Golgi lumen]
(Rattus norvegicus)
MUC20 [Golgi lumen]
(Bos taurus)
MUC20 [Golgi lumen]
(Canis familiaris)
MUC20 [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-(N-acetylamino)galactosyl-L-serine at unknown position
PsiMod Name
O-(N-acetylamino)galactosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.
Cross References
RefSeq
NP_065841.1
,
NP_689886.3
,
NP_001278762.1
,
NP_001269435.1
OpenTargets
ENSG00000176945
ENSEMBL
ENSP00000479182
,
ENST00000620530
,
ENST00000627739
,
ENST00000630334
,
ENST00000615394
,
ENSP00000414350
,
ENSP00000479947
,
ENSP00000405629
,
ENSP00000485921
,
ENSP00000485837
,
ENSP00000485855
,
ENST00000610415
,
ENSP00000483878
,
ENST00000447234
,
ENST00000445522
,
ENST00000625274
HPA
ENSG00000176945-MUC20
PRO
Q8N307
Pharos - Targets
Q8N307
GlyGen
Q8N307
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BPY3 F118B
0.527
2
UniProt:P49411 TUFM
2
TUFM [mitochondrial matrix]
(R-HSA-5389846)
TUFM [mitochondrial outer membrane]
(R-HSA-9754777)
0.527
2
UniProt:Q8IYL2 TRMT44
1
TRMT44 [cytosol]
(R-HSA-6788685)
0.527
2
UniProt:Q9HD47 RANGRF
1
RANGRF [cytosol]
(R-HSA-5216063)
0.527
2
UniProt:P62330 ARF6
2
ARF6 [recycling endosome membrane]
(R-HSA-2029049)
ARF6 [cytosol]
(R-HSA-8871121)
0.527
2
UniProt:P68366 TUBA4A
9
TUBA4A [cytosol]
(R-HSA-191694)
TUBA4A [axonemal microtubule]
(R-HSA-5610443)
TUBA4A [extracellular region]
(R-HSA-350734)
Polyglutamyl-TUBA4A [cytosol]
(R-HSA-8867386)
L-isoglutamyl polyglycyl-TUBA4A [cytosol]
(R-HSA-8867378)
TUBA4A unfolded [cytosol]
(R-HSA-392771)
TUBA4A folding intermediate [cytosol]
(R-HSA-392800)
Ac K40 TUBA4A [axonemal microtubule]
(R-HSA-5624859)
AcK-TUBA4A [cytosol]
(R-HSA-5618318)
0.527
2
UniProt:Q9H4B7 TUBB1
6
TUBB1 folding intermediate [cytosol]
(R-HSA-392793)
TUBB1 unfolded [cytosol]
(R-HSA-392782)
Polyglycyl-TUBB1 [cytosol]
(R-HSA-8867450)
Polyglutamyl-TUBB1 [cytosol]
(R-HSA-8867413)
TUBB1 [axonemal microtubule]
(R-HSA-5610437)
TUBB1 [cytosol]
(R-HSA-191703)
0.527
2
UniProt:O75879 GATB
0.527
2
UniProt:Q14CZ7 FAKD3
0.527
2
UniProt:Q13509 TUBB3
6
TUBB3 [cytosol]
(R-HSA-190532)
TUBB3 [axonemal microtubule]
(R-HSA-5610436)
Polyglutamyl-TUBB3 [cytosol]
(R-HSA-8867464)
Polyglycyl-TUBB3 [cytosol]
(R-HSA-8867372)
TUBB3 unfolded [cytosol]
(R-HSA-392770)
TUBB3 folding intermediate [cytosol]
(R-HSA-392806)
0.527
2
UniProt:Q92572 AP3S1
2
AP3S1 [Golgi membrane]
(R-HSA-434343)
AP3S1 [cytoplasmic vesicle membrane]
(R-HSA-434205)
0.527
2
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