Pre-pro-defensins are cleaved to remove the signal peptide

Stable Identifier
R-HSA-1462023
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Golgi lumen
ReviewStatus
5/5
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Pre-pro-defensins are cleaved to remove the signal peptide
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Pre-pro-defensins are cleaved in the golgi by undefined proteases which remove the signal peptide (Yang et al. 2004, Pazgier et al. 2006). Subsequently, alpha-defensins are cleaved again to produce the biologically active mature peptide. Beta defensins have much shorter propieces and may be active once the signal peptide is removed. Further N-terminal processing of the mature defensin may yield multiple forms of the same peptide (Pazgier et al. 2006).
Literature References
PubMed ID Title Journal Year
12949495 Defensins: antimicrobial peptides of innate immunity

Ganz, T

Nat Rev Immunol 2003
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Orthologous Events
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Pre-pro-defensins are cleaved to remove the signal peptide (Rattus norvegicus)
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Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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