pro-defensin alpha 5 is stored in Paneth cell granules

Stable Identifier
R-HSA-1461995
Type
Reaction [transition]
Species
Homo sapiens
Compartment
secretory granule lumen, Golgi lumen
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
pro-defensin alpha 5 is stored in Paneth cell granules
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pro-defensin alpha 5 is stored in the granules of Paneth cells in the small intestine (Porter et al. 1997). This pro-peptide has some antimicrobial activity but is not as effective as the mature peptide (Ghosh et al. 2002).

Literature References
PubMed ID Title Journal Year
9169779 Localization of human intestinal defensin 5 in Paneth cell granules

Porter, EM, Liu, L, Oren, A, Anton, PA, Ganz, T

Infect Immun 1997
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)
pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)