pro-defensin alpha 5 is stored in Paneth cell granules

Stable Identifier
R-HSA-1461995
Type
Reaction [transition]
Species
Homo sapiens
Compartment
secretory granule lumen, Golgi lumen
ReviewStatus
5/5
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pro-defensin alpha 5 is stored in Paneth cell granules
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Pro-defensin alpha 5 is stored in the granules of Paneth cells in the small intestine (Porter et al. 1997). This pro-peptide has some antimicrobial activity but is not as effective as the mature peptide (Ghosh et al. 2002).
Literature References
PubMed ID Title Journal Year
9169779 Localization of human intestinal defensin 5 in Paneth cell granules

Anton, PA, Ganz, T, Oren, A, Liu, L, Porter, EM

Infect Immun 1997
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Orthologous Events
pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)
pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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