pro-HD5 is cleaved by trypsin

Stable Identifier
R-HSA-1461993
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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pro-HD5 is cleaved by trypsin
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Pro HD5 is stored and secreted from granules of Paneth cells in the small intestine (Porter et al. 1997, Cunliffe et al. 2001). The serine protease tryspin colocalizes to these granules as the inactive zymogen trypsinogen. Removal of the defensin propiece occurs extracellularly after release in to the crypt lumen, and is mediated by trypsin 2 (anionic trypsin) and/or trypsin-3 (mesotrypsin) which are converted to their active forms by enteroprotease like enzymes or by autoactivation (Ghosh et al. 2002, Ouelette 2011).
Literature References
PubMed ID Title Journal Year
12021776 Paneth cell trypsin is the processing enzyme for human defensin-5

Ghosh, D, Porter, E, Shen, B, Lee, SK, Wilk, D, Drazba, J, Yadav, SP, Crabb, JW, Ganz, T, Bevins, CL

Nat Immunol 2002
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Catalyst Activity

serine-type peptidase activity of Trypsin 2, 3 [extracellular region]

Physical Entity
Trypsin 2, 3 [extracellular region] (Homo sapiens)
Activity
serine-type peptidase activity (GO:0008236)
Orthologous Events
pro-HD5 is cleaved by trypsin (Mus musculus)
pro-HD5 is cleaved by trypsin (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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