pro-HD5 is cleaved by trypsin

Stable Identifier
R-HSA-1461993
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Pro HD5 is stored and secreted from granules of Paneth cells in the small intestine (Porter et al. 1997, Cunliffe et al. 2001). The serine protease tryspin colocalizes to these granules as the inactive zymogen trypsinogen. Removal of the defensin propiece occurs extracellularly after release in to the crypt lumen, and is mediated by trypsin 2 (anionic trypsin) and/or trypsin-3 (mesotrypsin) which are converted to their active forms by enteroprotease like enzymes or by autoactivation (Ghosh et al. 2002, Ouelette 2011).

Literature References
PubMed ID Title Journal Year
12021776 Paneth cell trypsin is the processing enzyme for human defensin-5

Ghosh, D, Porter, E, Shen, B, Lee, SK, Wilk, D, Drazba, J, Yadav, SP, Crabb, JW, Ganz, T, Bevins, CL

Nat Immunol 2002
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type peptidase activity of Trypsin 2, 3 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created