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DEFA3(65-94) [extracellular region]
Stable Identifier
R-HSA-1461983
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Defensin alpha 3, Neutrophil defensin 3, DEFA3, DEF3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Alpha-defensins (Homo sapiens)
Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 3 dimer [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 3 dimer [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 3 dimer [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin pore complex [plasma membrane] (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 3 dimer [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
Alpha-defensins form biologically active dimers (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 3 dimer [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
Alpha-defensins [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
HNP1-3 bind CD4 (Homo sapiens)
Defensins alpha 1-3 [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
Defensins alpha 1-3:CD4 [plasma membrane] (Homo sapiens)
Defensins alpha 1-3 [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
HNP1-3 bind gp120 (Homo sapiens)
Defensins alpha 1-3 [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
HNP1-3:gp120 [viral envelope] (Homo sapiens)
Defensins alpha 1-3 [extracellular region] (Homo sapiens)
DEFA3(65-94) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59666 DEFA3
Gene Names
DEFA3, DEF3
Chain
signal peptide:1-19, propeptide:20-38, chain:39-94, peptide:65-94, peptide:66-94
Reference Genes
BioGPS Gene:1668 DEFA3
COSMIC (genes):DEFA3 DEFA3
CTD Gene:1668 DEFA3
dbSNP Gene:1668 DEFA3
ENSEMBL:ENSG00000239839 DEFA3
ENSEMBL_homo_sapiens_GENE:ENSG00000239839.7 DEFA3
HGNC:2762 DEFA3
KEGG Gene (Homo sapiens):1668 DEFA3
Monarch:1668 DEFA3
NCBI Gene:1668 DEFA3
OMIM:604522 DEFA3
Reference Transcript
RefSeq:NM_005217.3 DEFA3
Other Identifiers
11721438_s_at
1668
17074313
17074322
17074331
205033_PM_s_at
205033_s_at
3122764
3122765
3122766
3122772
3122785
3122786
3122787
3122793
3122806
3122807
3122808
3122813
31506_s_at
31793_at
8149116
8149126
8149137
A_23_P31816
GO:0002227
GO:0002376
GO:0003674
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0006952
GO:0019731
GO:0023052
GO:0030520
GO:0031410
GO:0031640
GO:0035578
GO:0042742
GO:0042803
GO:0043226
GO:0050829
GO:0050830
GO:0050832
GO:0051607
GO:0051673
GO:0061844
GO:0070062
GO:0071222
GO:0098542
HMNXSV003020261
ILMN_1679357
ILMN_1725661
ILMN_2102721
ILMN_2165289
ILMN_2193213
M26602_at
PH_hs_0030636
TC08000910.hg
TC08002630.hg
TC08002631.hg
g12621915_3p_s_at
Participates
as a member of
Alpha-defensins [extracellular region] (Homo sapiens)
Defensins alpha 1-3 [extracellular region] (Homo sapiens)
as a component of
Defensin alpha 3 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
DEFA3(65-94) [azurophil granule lumen]
DEFA3(66-94) [extracellular region]
DEFA3(20-64) [Golgi lumen]
DEFA3(65-94) [Golgi lumen]
DEFA3(20-94) [Golgi lumen]
DEFA3(1-94) [Golgi lumen]
Inferred To
Defa35 [extracellular region]
(Mus musculus)
Defa28 [extracellular region]
(Mus musculus)
Defa31 [extracellular region]
(Mus musculus)
Defa40 [extracellular region]
(Mus musculus)
Np4 [extracellular region]
(Rattus norvegicus)
Defa2 [extracellular region]
(Mus musculus)
Defa26 [extracellular region]
(Mus musculus)
Defa10 [extracellular region]
(Rattus norvegicus)
Homologues of DEFA1(65-94) [extracellular region]
(Mus musculus)
Homologues of DEFA1(65-94) [extracellular region]
(Rattus norvegicus)
Defa9 [extracellular region]
(Rattus norvegicus)
Defal1 [extracellular region]
(Rattus norvegicus)
Defa [extracellular region]
(Rattus norvegicus)
Defa23 [extracellular region]
(Mus musculus)
Defa39 [extracellular region]
(Mus musculus)
Defa42 [extracellular region]
(Mus musculus)
Defa21 [extracellular region]
(Mus musculus)
Defa25 [extracellular region]
(Mus musculus)
Defa29 [extracellular region]
(Mus musculus)
Defa34 [extracellular region]
(Mus musculus)
Defa8 [extracellular region]
(Rattus norvegicus)
Defa30 [extracellular region]
(Mus musculus)
Defa11 [extracellular region]
(Rattus norvegicus)
Defa3 [extracellular region]
(Mus musculus)
Defa6 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000064390 [extracellular region]
(Rattus norvegicus)
Defa5 [extracellular region]
(Mus musculus)
DEFA1(65-94) [extracellular region]
(Mus musculus)
DEFA1(65-94) [extracellular region]
(Rattus norvegicus)
Defa38 [extracellular region]
(Mus musculus)
Defa22 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Rattus norvegicus)
Defa17 [extracellular region]
(Mus musculus)
Defa41 [extracellular region]
(Mus musculus)
Defa20 [extracellular region]
(Mus musculus)
Defa36 [extracellular region]
(Mus musculus)
AY761185 [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_005208.1
OpenTargets
ENSG00000239839
GeneCards
P59666
HPA
ENSG00000239839-DEFA3
Ensembl
ENSG00000239839
,
ENSP00000328359
,
ENST00000327857
PRO
P59666
Pharos - Targets
P59666
PDB
1ZMK
,
1ZMH
,
1DFN
,
2PM5
,
2PM4
,
1ZMI
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