RALA hydrolyzes GTP

Stable Identifier
R-HSA-1458485
Type
Reaction
Species
Homo sapiens
Compartment
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RALA is a guanine nucleotide binding protein that hydrolyzes bound GTP to yield GDP and phosphate. RGC1 and RGC2 are GAPs (GTPase-activating proteins) that activate the GTPase activity of RALA. Insulin activates AKT, which phosphorylates RGC2, inactivating the GAP activity of RGC1:RGC2 and allowing RALA:GTP to accumulate.

Literature References
PubMed ID Title Journal Year
8664345 Characterization of human platelet GTPase activating protein for the Ral GTP-binding protein

Bhullar, RP, Seneviratne, HD

Biochim Biophys Acta 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of GGC-RALA:GTP [cytoplasmic vesicle membrane]
Physical Entity
Activity
This event is regulated
Positively by
Inferred From
Authored
Reviewed
Created