RALA hydrolyzes GTP

Stable Identifier
R-HSA-1458485
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
ReviewStatus
5/5
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RALA hydrolyzes GTP
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As inferred from mouse, RGC1:RGC2 (RALGAPB:RALGAPA2) activate the GTPase activity of RALA (Chen et al. 2011).

RALA is a guanine nucleotide binding protein that hydrolyzes bound GTP to yield GDP and phosphate. RGC1 and RGC2 are GAPs (GTPase-activating proteins) that activate the GTPase activity of RALA. Insulin activates AKT, which phosphorylates RGC2, inactivating the GAP activity of RGC1:RGC2 and allowing RALA:GTP to accumulate.

Literature References
PubMed ID Title Journal Year
8664345 Characterization of human platelet GTPase activating protein for the Ral GTP-binding protein

Bhullar, RP, Seneviratne, HD

Biochim Biophys Acta 1996
Participants
Input
Output
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as an event of
Catalyst Activity

GTPase activity of GGC-RALA:GTP [cytoplasmic vesicle membrane]

Physical Entity
GGC-RALA:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
This event is regulated
Positively by
Regulator
RGC1:RGC2 [cytosol] (Homo sapiens)
Inferred From
RalA Hydrolyzes GTP (Mus musculus)
Authored
May, B  (2011-07-17)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-21)
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