Collagen type I degradation by MMP1,2,8,13, PRSS2

Stable Identifier
R-HSA-1454822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Collagen type I degradation by MMP1,2,8,13, PRSS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type I. MMP2, also known as Gelatinase-A, was found to cleave collagen type I fibrils (Aimes & Quigley 1995). Though this was disputed (Seltzre & Eisen 1999) there is a structural explanation for the apparent discrepancies in experimental data (Patterson et al. 2001). In addition trypsin-2 is able to degrade native soluble type I collagen (Moilanen et al. 2003). Degradation is represented here at a theoretical end point where every alpha strand has been cleaved.
Literature References
PubMed ID Title Journal Year
15257288 Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

Visse, R, Fields, GB, Lauer-Fields, JL, Nagase, H, Yoshida, N, Dinakarpandian, D, Chung, L

EMBO J 2004
3038863 The collagen substrate specificity of human neutrophil collagenase

Hibbs, MS, Hasty, KA, Jeffrey, JJ, Welgus, HG

J Biol Chem 1987
6270089 The collagen substrate specificity of human skin fibroblast collagenase

Eisen, AZ, Jeffrey, JJ, Welgus, HG

J Biol Chem 1981
7890717 Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments

Quigley, JP, Aimes, RT

J Biol Chem 1995
8576151 Biochemical characterization of human collagenase-3

Smith, B, López-Otin, C, Knight, G, Knäuper, V, Murphy, G

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MMP1,2,8,13, PRSS2 [extracellular region]

Physical Entity
MMP1,2,8,13, PRSS2 [extracellular region] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Bos taurus)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Caenorhabditis elegans)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Canis familiaris)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Gallus gallus)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Xenopus tropicalis)
Authored
Jupe, S  (2011-07-12)
Reviewed
Sorsa, T  (2012-10-08)
Created
Jupe, S  (2011-07-18)
Cite Us!