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SLC2A4 (GLUT4) vesicle fuses with the plasma membrane
Stable Identifier
R-HSA-1449574
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After docking at the membrane VAMP2 on the vesicle interacts with SYNTAXIN-4 and SNAP23 on the plasma membrane to catalyze fusion of the vesicle with the plasma membrane. STXBP3 (MUNC18C) bound to STX4 prevents fusion until STXBP3 is phosphorylated.
Participants
Input
ATP [cytosol]
SLC2A4:ASPSCR1 [cytoplasmic vesicle membrane]
(Homo sapiens)
SNAP23 [plasma membrane]
(Homo sapiens)
STX4:STXBP3 (MUNC18C) [plasma membrane]
(Homo sapiens)
VAMP2 [cytoplasmic vesicle membrane]
(Homo sapiens)
Output
ADP [cytosol]
ASPSCR1 [cytoplasmic vesicle membrane]
(Homo sapiens)
p-Y521-STXBP3 [plasma membrane]
(Homo sapiens)
SLC2A4 [plasma membrane]
(Homo sapiens)
VAMP2:STX4:SNAP23 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
Inferred From
Fusion of Glut4 Vesicle with the Plasma Membrane (Mus musculus)
Authored
May, B (2011-07-13)
Reviewed
Klip, A (2012-08-21)
Created
May, B (2011-07-15)
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