14-3-3 binds p-5S,T642-AS160 (TBC1D4)

Stable Identifier
R-HSA-1445149
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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AS160 (TBC1D4) phosphorylated on serines 318, 341, 570, 588, and 751 and threonine 642 binds to all 14-3-3 proteins, although binding to 14-3-3 delta (YWHAZ) is comparatively low (Ramm et al. 2006, Howlett et al. 2007, Ngo et al. 2009, Treebak et al. 2009, Koumanov et al. 2011). As inferred from mouse, binding to 14-3-3 does not interfere with the interaction between AS160 and IRAP (LNPEP).

Literature References
PubMed ID Title Journal Year
19252894 Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

Treebak, JT, Frøsig, C, Pehmøller, C, Chen, S, Maarbjerg, SJ, Brandt, N, Mackintosh, C, Zierath, JR, Hardie, DG, Kiens, B, Richter, EA, Pilegaard, H, Wojtaszewski, JF

Diabetologia 2009
21454690 AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane

Koumanov, F, Richardson, JD, Murrow, BA, Holman, GD

J Biol Chem 2011
19013499 Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

Ngo, S, Barry, JB, Nisbet, JC, Prins, JB, Whitehead, JP

Mol Cell Endocrinol 2009
16880201 A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160

Ramm, G, Larance, M, Guilhaus, M, James, DE

J Biol Chem 2006
17369524 Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

Howlett, KF, Sakamoto, K, Garnham, A, Cameron-Smith, D, Hargreaves, M

Diabetes 2007
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