Reactome | 14-3-3 binds p-5S,T642-AS160 (TBC1D4)

14-3-3 binds p-5S,T642-AS160 (TBC1D4)

Stable Identifier

R-HSA-1445149

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane, cytosol

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AS160 (TBC1D4) phosphorylated on serines 318, 341, 570, 588, and 751 and threonine 642 binds to all 14-3-3 proteins, although binding to 14-3-3 delta (YWHAZ) is comparatively low (Ramm et al. 2006, Howlett et al. 2007, Ngo et al. 2009, Treebak et al. 2009, Koumanov et al. 2011). As inferred from mouse, binding to 14-3-3 does not interfere with the interaction between AS160 and IRAP (LNPEP).

Literature References

PubMed ID	Title	Journal	Year
21454690	AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane Holman, GD, Koumanov, F, Richardson, JD, Murrow, BA	J Biol Chem	2011
19252894	Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle Brandt, N, Richter, EA, Maarbjerg, SJ, Kiens, B, Mackintosh, C, Treebak, JT, Wojtaszewski, JF, Frøsig, C, Zierath, JR, Pilegaard, H, Pehmøller, C, Chen, S, Hardie, DG	Diabetologia	2009
19013499	Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes Barry, JB, Ngo, S, Prins, JB, Whitehead, JP, Nisbet, JC	Mol Cell Endocrinol	2009
16880201	A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160 James, DE, Guilhaus, M, Larance, M, Ramm, G	J Biol Chem	2006
17369524	Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle Hargreaves, M, Sakamoto, K, Howlett, KF, Garnham, A, Cameron-Smith, D	Diabetes	2007