Reactome | MMP12 [extracellular region]

MMP12 [extracellular region]

Stable Identifier

R-HSA-1442474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Macrophage metalloelastase, MMP12_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P39900 MMP12

Gene Names

MMP12, HME

Chain

signal peptide:1-16, propeptide:17-105, chain:106-470

Reference Genes

BioGPS Gene:4321 MMP12

COSMIC (genes):MMP12 MMP12

CTD Gene:4321 MMP12

dbSNP Gene:4321 MMP12

ENSEMBL:ENSG00000262406.3 MMP12

HGNC:7158 MMP12

KEGG Gene (Homo sapiens):4321 MMP12

Monarch:4321 MMP12

NCBI Gene:4321 MMP12

OMIM:601046 MMP12

UCSC:P39900 MMP12

Reference Transcript

RefSeq:NM_002426.5 MMP12

Other Identifiers

0000780193

11724589_s_at

1481_at

1482_g_at

16743751

204580_PM_at

204580_at

3388860

3388861

3388864

3388865

3388866

3388870

3388871

3388872

3388873

3388874

3388876

3388877

3388878

3388879

3388880

3388881

4321

7951297

A_23_P150316

A_23_P340698

GE57681

GO:0000122

GO:0001046

GO:0002376

GO:0003674

GO:0003677

GO:0004175

GO:0004222

GO:0004252

GO:0005509

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0006351

GO:0006355

GO:0006508

GO:0006606

GO:0006886

GO:0007155

GO:0008150

GO:0008233

GO:0008237

GO:0008270

GO:0010628

GO:0016787

GO:0022617

GO:0023052

GO:0030163

GO:0030198

GO:0030312

GO:0030574

GO:0031012

GO:0032727

GO:0035313

GO:0042060

GO:0043167

GO:0043226

GO:0043565

GO:0045944

GO:0046872

GO:0048286

GO:0048856

GO:0048870

GO:0050691

GO:0060054

GO:0060309

GO:0060339

GO:0060340

GO:0060435

GO:0098542

GO:0098586

GO:1901135

GO:1904645

GO:1904905

HMNXSV003020662

ILMN_1680512

ILMN_1768035

ILMN_2073758

L23808_at

PH_hs_0030872

TC11002237.hg

g4505206_3p_at

Participates

as a member of

as a candidate of

Inferred To

MMP7 [extracellular region] (Gallus gallus)

mmp1 [extracellular region] (Xenopus tropicalis)

Mmp1 [extracellular region] (Drosophila melanogaster)

MMP12 [extracellular region] (Bos taurus)

MMP12 [extracellular region] (Caenorhabditis elegans)

MMP12 [extracellular region] (Canis familiaris)

MMP12 [extracellular region] (Drosophila melanogaster)

MMP12 [extracellular region] (Mus musculus)

MMP12 [extracellular region] (Rattus norvegicus)

MMP12 [extracellular region] (Sus scrofa)

Homologues of MMP12 [extracellular region] (Caenorhabditis elegans)

Homologues of MMP12 [extracellular region] (Drosophila melanogaster)

Homologues of MMP12 [extracellular region] (Xenopus tropicalis)

LOC100489735 [extracellular region] (Xenopus tropicalis)

mmp8 [extracellular region] (Xenopus tropicalis)

zmp-5 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002417.2

ZINC - World Drugs

MMP12_HUMAN

Guide to Pharmacology - Targets

1636

OpenTargets

ENSG00000262406

ZINC - Substances

MMP12_HUMAN

ZINC - Biogenic

MMP12_HUMAN

ZINC target

P39900

PRO

P39900

PDB

5I0L, 1OS9, 4I03, 3RTS, 4H76, 3TSK, 5LAB, 1UTZ, 1YCM, 2HU6, 3RTT, 3F18, 2WOA, 6ELA, 3N2V, 3LK8, 3F17, 2OXZ, 2JXY, 2WO9, 3N2U, 5I3M, 2MLR, 1Y93, 2W0D, 1Z3J, 4GR8, 5N5K, 4H49, 5N5J, 6RD0, 7OVY, 1JK3, 1UTT, 3LKA, 3TS4, 2Z2D, 2KRJ, 5D3C, 4GR3, 2POJ, 1ROS, 1RMZ, 6RLY, 3LIR, 2MLS, 5L7F, 6EOX, 4GR0, 5I43, 3EHY, 5CZM, 2K9C, 3LIL, 4H30, 4GQL, 1JIZ, 5L79, 3EHX, 4H84, 6EKN, 3UVC, 3F15, 5D2B, 5I4O, 3F1A, 2OXW, 5I2Z, 2WO8, 3LIK, 2N8R, 3LJG, 5CXA, 3BA0, 3F16, 4GUY, 4IJO, 1OS2, 3NX7, 3F19, 4EFS, 2K2G, 6ENM, 2OXU

ZINC - Investigational

MMP12_HUMAN

ZINC - Metabolites

MMP12_HUMAN

IntEnz

3.4.24.65

GeneCards

P39900

HPA

ENSG00000262406-MMP12

Ensembl

ENSG00000262406, ENSP00000458585, ENST00000571244

Pharos - Targets

P39900

ZINC - Predictions - Purchasable

MMP12_HUMAN

HMDB Protein

HMDBP07803

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