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MMP12
Stable Identifier
R-HSA-1442474
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Macrophage metalloelastase, MMP12_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)
MMP1,2,3,7,9,12,13 [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
MMP2,3,4,9,10,12 [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Collagen type XII degradation by MMP12 (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Collagen type XVIII endostatin release (Homo sapiens)
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
MMP1-3, 7-9, 12, 13 [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)
Elastin-degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Homo sapiens)
MMP2,9,12,13 [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)
MMP3, plasmin, (MMP12) [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)
Laminin-332 degrading extracellular proteinases [extracellular region] (Homo sapiens)
Laminin gamma-2 degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)
Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
NID1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)
MMP1, MMP9, MMP12, ELANE [extracellular region] (Homo sapiens)
MMP12 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39900 MMP12
Gene Names
MMP12, HME
Chain
signal peptide:1-16, propeptide:17-105, chain:106-470
Reference Genes
BioGPS Gene:4321 MMP12
CTD Gene:4321 MMP12
dbSNP Gene:4321 MMP12
ENSEMBL:ENSG00000262406 MMP12
HGNC:7158 MMP12
KEGG Gene (Homo sapiens):hsa:4321 MMP12
KEGG Gene (Homo sapiens):MMP12 MMP12
Monarch:4321 MMP12
NCBI Gene:4321 MMP12
OMIM:601046 MMP12
UCSC:P39900 MMP12
Reference Transcript
RefSeq:NM_002426.5 MMP12
Other Identifiers
0000780193
11724589_s_at
1481_at
1482_g_at
16743751
1JIZ
1JK3
1OS2
1OS9
1RMZ
1ROS
1UTT
1UTZ
1Y93
1YCM
1Z3J
204580_at
2HU6
2JXY
2K2G
2K9C
2KRJ
2MLR
2MLS
2N8R
2OXU
2OXW
2OXZ
2POJ
2W0D
2WO8
2WO9
2WOA
2Z2D
3388860
3388861
3388864
3388865
3388866
3388870
3388871
3388872
3388873
3388874
3388876
3388877
3388878
3388879
3388880
3388881
3BA0
3EHX
3EHY
3F15
3F16
3F17
3F18
3F19
3F1A
3LIK
3LIL
3LIR
3LJG
3LK8
3LKA
3N2U
3N2V
3NX7
3RTS
3RTT
3TS4
3TSK
3UVC
4321
4EFS
4GQL
4GR0
4GR3
4GR8
4GUY
4H30
4H49
4H76
4H84
4I03
4IJO
5CXA
5CZM
5D2B
5D3C
5I0L
5I2Z
5I3M
5I43
5I4O
5L79
5L7F
5LAB
7951297
A_23_P150316
A_23_P340698
CCDS73375
ENSG00000262406
ENSP00000458585
ENST00000571244
EntrezGene:4321
g4505206_3p_at
GE57681
GO:0000122
GO:0001047
GO:0004175
GO:0004222
GO:0004252
GO:0005509
GO:0005518
GO:0005576
GO:0005578
GO:0005615
GO:0005634
GO:0005737
GO:0006508
GO:0006606
GO:0008233
GO:0008237
GO:0008270
GO:0010628
GO:0016787
GO:0022617
GO:0030574
GO:0031012
GO:0035313
GO:0042060
GO:0043565
GO:0045944
GO:0046872
GO:0050691
GO:0060054
GO:0060339
GO:0060340
GO:0098586
GO:1902741
HGNC:7158
Hs.1695
ILMN_1680512
ILMN_1768035
ILMN_2073758
L23808_at
MIM:601046
MMP12
MMP12-201
NM_002426
NP_002417
PF00045
PF00413
PF01471
PH_hs_0030872
PR00138
SM00120
SM00235
TC11002237.hg
uc031yde.2
UPI00000422BE
Participant Of
hasCandidate
MMP1, 3, 13, (2, 7-12, 19) [extracellular region]
MMP3, plasmin, (MMP12) [extracellular region]
hasMember
Elastin-degrading extracellular proteinases [extracellular region]
Endostatin-releasing proteases [extracellular region]
Laminin gamma-2 degrading extracellular proteinases [extracellular region]
MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region]
MMP1, MMP9, MMP12, ELANE [extracellular region]
MMP1,2,3,7,9,12,13 [extracellular region]
MMP1-3, 7-9, 12, 13 [extracellular region]
MMP2,3,4,9,10,12 [extracellular region]
MMP2,9,12,13 [extracellular region]
Inferred To
MMP12 [extracellular region] (Canis familiaris)
MMP12 [extracellular region] (Drosophila melanogaster)
MMP12 [extracellular region] (Mus musculus)
MMP12 [extracellular region] (Rattus norvegicus)
MMP12 [extracellular region] (Sus scrofa)
MMP12 [extracellular region] (Xenopus tropicalis)
Homologues of MMP12 [extracellular region] (Xenopus tropicalis)
Cross References
RefSeq
NP_002417.2
ZINC - World Drugs
MMP12_HUMAN
Brenda
3.4.24.65
ZINC - Substances
MMP12_HUMAN
ZINC target
P39900
ZINC - Biogenic
MMP12_HUMAN
PRO
P39900
PDB
1Z3J
,
3TS4
,
3TSK
,
2HU6
,
2JXY
,
3UVC
,
2K2G
,
4EFS
,
4GQL
,
2K9C
,
3N2U
,
1ROS
,
3N2V
,
1UTT
,
3NX7
,
1UTZ
,
1Y93
,
3RTS
,
1YCM
,
3RTT
,
3LIL
,
3LIR
,
1JK3
,
3LJG
,
1OS2
,
3LK8
,
1OS9
,
3LKA
,
1RMZ
,
5L79
,
3F17
,
5L7F
,
3F18
,
5LAB
,
3F19
,
5N5J
,
3F1A
,
1JIZ
,
5N5K
,
3LIK
,
3BA0
,
3EHX
,
5I2Z
,
5I3M
,
3EHY
,
5I43
,
3F15
,
5I4O
,
3F16
,
5CXA
,
2WO8
,
2WO9
,
5CZM
,
5D2B
,
2WOA
,
2Z2D
,
5D3C
,
5I0L
,
2OXU
,
2N8R
,
4H30
,
4GUY
,
2MLS
,
4GR8
,
2MLR
,
4GR3
,
2KRJ
,
4GR0
,
4IJO
,
2W0D
,
2POJ
,
4I03
,
4H84
,
2OXZ
,
4H76
,
2OXW
,
4H49
ZINC - Metabolites
MMP12_HUMAN
GeneCards
P39900
DOCK Blaster
1Y93
,
1ROS
,
4GR8
,
4GR0
,
4H30
,
4GR3
,
2OXW
,
2OXZ
,
3LKA
,
5D3C
,
1OS2
,
5LAB
,
3LK8
,
3RTS
,
5I4O
,
3RTT
,
5D2B
,
3LIK
,
3LIL
,
3LJG
,
3LIR
,
4H84
,
1RMZ
,
5CXA
,
3TSK
,
5L7F
,
3TS4
,
3F1A
,
3NX7
,
1UTZ
,
1UTT
,
4EFS
,
3BA0
,
1JK3
,
3F16
,
5I43
,
3F17
,
3F18
,
3F19
,
5I3M
,
4H76
,
4I03
,
4GUY
,
3F15
,
5L79
,
3UVC
,
5I2Z
,
3EHX
,
3EHY
,
2HU6
,
2WO9
,
2WO8
,
4H49
,
2WOA
,
4GQL
,
5CZM
,
1JIZ
,
2W0D
,
2OXU
,
4IJO
,
3N2V
,
3N2U
,
1OS9
,
5I0L
ZINC - Predictions - Purchasable
MMP12_HUMAN
HMDB Protein
HMDBP07803
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