JAK2 binds to p-KIT

Stable Identifier
R-HSA-1433451
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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JAK2 binds to p-KIT
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Janus kinase 2 (JAK2) plays an important role in SCF-induced proliferation (Radosevic et al. 2004). JAK2 was observed to pre-associate with KIT, with increased association after SCF stimulation of KIT (Weiler et al. 1996).

Literature References
PubMed ID Title Journal Year
8611693 JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

Keller, JR, Linnekin, D, Longo, DL, Mou, S, Ruscetti, FW, Ferris, DK, DeBerry, CS, Weiler, SR

Blood 1996
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Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-07-11)
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