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PTP-RO interacts with p-c-Kit complex
Stable Identifier
R-HSA-1433423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
PTP-RO interacts with p-c-Kit complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Tyrosine phosphatase PTPRO associates constitutively with c-Kit independently of SCF stimulation. PTPRO undergoes phosphorylation upon SCF stimulation. The PTPRO binding site on c-Kit and the molecular mechanism by which c-Kit signaling is regulated by PTPRO have not been determined.
Literature References
PubMed ID
Title
Journal
Year
10397721
The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor
London, R
,
Jiang, S
,
Avraham, H
,
Taniguchi, Y
,
Schinkmann, K
Blood
1999
Participants
Input
KIT [plasma membrane]
(Homo sapiens)
PTPRU [plasma membrane]
(Homo sapiens)
Output
PTPRU:KIT [plasma membrane]
(Homo sapiens)
Participates
as an event of
Signaling by SCF-KIT (Homo sapiens)
Orthologous Events
PTP-RO interacts with p-c-Kit complex (Bos taurus)
PTP-RO interacts with p-c-Kit complex (Canis familiaris)
PTP-RO interacts with p-c-Kit complex (Danio rerio)
PTP-RO interacts with p-c-Kit complex (Mus musculus)
PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)
PTP-RO interacts with p-c-Kit complex (Sus scrofa)
Authored
Garapati, P V (2011-07-11)
Reviewed
Rönnstrand, L (2011-08-22)
Created
Garapati, P V (2011-07-11)
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