PTP-RO interacts with p-c-Kit complex

Stable Identifier
R-HSA-1433423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tyrosine phosphatase PTPRO associates constitutively with c-Kit independently of SCF stimulation. PTPRO undergoes phosphorylation upon SCF stimulation. The PTPRO binding site on c-Kit and the molecular mechanism by which c-Kit signaling is regulated by PTPRO have not been determined.

Literature References
PubMed ID Title Journal Year
10397721 The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor

Taniguchi, Y, London, R, Schinkmann, K, Jiang, S, Avraham, H

Blood 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created