Reactome | Processing of SCF isoform 1

Processing of SCF isoform 1

Stable Identifier

R-HSA-1433374

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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SCF exists as two alternatively spliced variants, a soluble form and a membrane-bound form differing in one exon (exon 6). Both isoforms are initially membrane bound with an extracellular domain, a transmembrane segment and an intracellular region. The longer isoform is rapidly cleaved to generate a 165 aa soluble protein knows as sSCF. The SCF transcript that lacks exon 6 encodes a glycoprotein that remains membrane-bound (mSCF). Both mSCF and sSCF are bioactive but different in their efficacy in c-kit activation.
Proteases including matrix metalloprotease-9 (Heissig et al., 2002), Chymase-1 (Longley et al., 1997) and several members of the ADAMs family (Kawaguchi et al, 2007; Amour et al, 2002; Chesneau et al, 2003; Mohan et al, 2002; Roghani et al, 1999; Zou et al, 2004) have been suggested to have a role in the processing of sSCF.

Literature References

PubMed ID	Title	Journal	Year
9256427	Chymase cleavage of stem cell factor yields a bioactive, soluble product Longley, BJ, Tyrrell, L, Ma, Y, Williams, DA, Halaban, R, Langley, K, Lu, HS, Schechter, NM	Proc Natl Acad Sci U S A	1997
17344430	Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19 Kawaguchi, N, Horiuchi, K, Becherer, JD, Toyama, Y, Besmer, P, Blobel, CP	J Cell Sci	2007
15526160	Signal transduction via the stem cell factor receptor/c-Kit Rönnstrand, L	Cell Mol Life Sci	2004
12062105	Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand Heissig, B, Hattori, K, Dias, S, Friedrich, M, Ferris, B, Hackett, NR, Crystal, RG, Besmer, P, Lyden, D, Moore, MA, Werb, Z, Rafii, S	Cell	2002