Reactome | BUB1B [cytosol]

BUB1B [cytosol]

Stable Identifier

R-HSA-141436

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

hBUBR1

Icon

Locations in the PathwayBrowser for interactor UniProt:Q12834 CDC20

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60566 BUB1B

Gene Names

BUB1B, BUBR1, MAD3L, SSK1

Chain

chain:1-1050

Reference Genes

BioGPS Gene:701 BUB1B

COSMIC (genes):BUB1B BUB1B

CTD Gene:701 BUB1B

dbSNP Gene:701 BUB1B

ENSEMBL:ENSG00000156970 BUB1B

ENSEMBL_homo_sapiens_GENE:ENSG00000156970.13 BUB1B

HGNC:1149 BUB1B

KEGG Gene (Homo sapiens):701 BUB1B

Monarch:701 BUB1B

NCBI Gene:701 BUB1B

OMIM:602860 BUB1B

UCSC:O60566 BUB1B

Reference Transcript

RefSeq:NM_001211.5 BUB1B

Other Identifiers

11720647_a_at

16799426

203755_PM_at

203755_at

35699_at

3589700

3589701

3589702

3589704

3589706

3589707

3589710

3589712

3589713

3589714

3589716

3589718

3589719

3589720

3589721

3589722

3589723

3589725

3589726

3589728

3589729

3589730

3589731

3589732

3589734

3589735

3589737

3589738

3589739

3589740

701

7982663

A_14_P121953

A_23_P163481

GE54489

GO:0000166

GO:0000278

GO:0000775

GO:0000776

GO:0000940

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005680

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006915

GO:0007049

GO:0007059

GO:0007091

GO:0007094

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0022414

GO:0023052

GO:0033597

GO:0043226

GO:0048471

GO:0051301

GO:0051754

GO:0071459

GO:0106310

GO:0140013

GO:0140014

GO:0140096

HMNXSV003036813

ILMN_1797307

PH_hs_0002907

TC15000276.hg

g5729749_3p_at

Participates

as a component of

as an input of

Formation of the MCC complex (Homo sapiens)

Inferred To

bub1b [cytosol] (Xenopus tropicalis)

bub1 [cytosol] (Dictyostelium discoideum)

BUB1B [cytosol] (Bos taurus)

BUB1B [cytosol] (Caenorhabditis elegans)

BUB1B [cytosol] (Canis familiaris)

BUB1B [cytosol] (Drosophila melanogaster)

BUB1B [cytosol] (Gallus gallus)

BUB1B [cytosol] (Mus musculus)

BUB1B [cytosol] (Saccharomyces cerevisiae)

BUB1B [cytosol] (Schizosaccharomyces pombe)

BUB1B [cytosol] (Sus scrofa)

Bub1b [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001202.4

Guide to Pharmacology - Targets

1950

OpenTargets

ENSG00000156970

GeneCards

O60566

HPA

ENSG00000156970-BUB1B

Ensembl

ENSP00000287598, ENST00000287598, ENSP00000398470, ENST00000412359, ENSG00000156970

PRO

O60566

Pharos - Targets

O60566

Orphanet

15384

HMDB Protein

HMDBP01451

PDB

2WVI, 5KHU, 6TLJ, 5K6S, 5SWF, 5LCW, 5JJA, 4GGD, 3SI5

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.975	38
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.932	13
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.905	14
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.905	8
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [nucleoplasm] (R-HSA-174115) ANAPC4 [cytosol] (R-HSA-174168)	0.823	12
UniProt:Q13042 CDC16	2	CDC16 [nucleoplasm] (R-HSA-174049) CDC16 [cytosol] (R-HSA-174156)	0.788	5
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.788	5
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.752	5
UniProt:Q9UJX6 ANAPC2	2	ANAPC2 [cytosol] (R-HSA-174229) ANAPC2 [nucleoplasm] (R-HSA-174141)	0.725	4
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.715	14
UniProt:Q8NG31-2 KNL1			0.703	10
UniProt:Q9UJX3 ANAPC7	2	ANAPC7 [nucleoplasm] (R-HSA-174204) ANAPC7 [cytosol] (R-HSA-174242)	0.669	3
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.643	3
UniProt:Q96DE5 ANAPC16	2	ANAPC16 [nucleoplasm] (R-HSA-6805137) ANAPC16 [cytosol] (R-HSA-6805138)	0.643	3
UniProt:Q02224 CENPE	1	CENPE [cytosol] (R-HSA-376245)	0.581	4
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.576	3
UniProt:Q8BGZ4	2	Cdc23 [nucleoplasm] (R-MMU-174228) Cdc23 [cytosol] (R-MMU-174137)	0.564	3
UniProt:Q99JP4	2	Cdc26 [nucleoplasm] (R-MMU-174216) Cdc26 [cytosol] (R-MMU-174052)	0.564	3
UniProt:Q9H081 MIS12	1	MIS12 [cytosol] (R-HSA-375313)	0.564	2
UniProt:Q8R349	2	Cdc16 [nucleoplasm] (R-MMU-174049) Cdc16 [cytosol] (R-MMU-174156)	0.564	2
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:Q9Z1B5	1	Mad2l1 [cytosol] (R-MMU-141400)	0.564	2
UniProt:O95229 ZWINT	1	ZWINT [cytosol] (R-HSA-376254)	0.528	2
UniProt:Q9UJX4 ANAPC5	2	ANAPC5 [nucleoplasm] (R-HSA-174153) ANAPC5 [cytosol] (R-HSA-174211)	0.527	2
UniProt:Q8NG31 KNL1	2	CASC5 [nucleoplasm] (R-HSA-606296) CASC5 [cytosol] (R-HSA-375322)	0.527	2
UniProt:Q8NHZ8 CDC26	2	CDC26 [nucleoplasm] (R-HSA-174216) CDC26 [cytosol] (R-HSA-174052)	0.527	2
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	2
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.499	3

Cite Us!