Reactome | MAD2L1 [cytosol]

MAD2L1 [cytosol]

Stable Identifier

R-HSA-141400

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HsMAD2, Mitotic spindle assembly checkpoint protein MAD2A (MAD2-like 1) (HsMAD2)

Icon

Locations in the PathwayBrowser for interactor UniProt:Q12834 CDC20

Expand all

External Reference Information

External Reference

UniProt:Q13257 MAD2L1

Gene Names

MAD2L1, MAD2

Chain

initiator methionine:, chain:2-205

Reference Genes

BioGPS Gene:4085 MAD2L1

COSMIC (genes):MAD2L1 MAD2L1

CTD Gene:4085 MAD2L1

dbSNP Gene:4085 MAD2L1

ENSEMBL:ENSG00000164109 MAD2L1

ENSEMBL_homo_sapiens_GENE:ENSG00000164109.14 MAD2L1

HGNC:6763 MAD2L1

KEGG Gene (Homo sapiens):4085 MAD2L1

Monarch:4085 MAD2L1

NCBI Gene:4085 MAD2L1

OMIM:601467 MAD2L1

UCSC:Q13257 MAD2L1

Reference Transcript

RefSeq:NM_002358.3 MAD2L1

Other Identifiers

11720185_a_at

11720186_s_at

11748136_a_at

1554768_PM_a_at

1554768_a_at

16979389

1721_g_at

203362_PM_s_at

203362_s_at

236312_PM_at

236312_at

2783726

2783727

2783728

2783729

2783730

2783731

2783732

2783733

2783734

2783735

2783736

2783737

2783739

2783742

2783743

2783744

3538716

3538718

3538720

3538721

3538722

37282_at

4085

46436_at

55824_at

8102560

A_23_P92441

GE59318

GO:0000070

GO:0000132

GO:0000278

GO:0000775

GO:0000776

GO:0000922

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0007010

GO:0007049

GO:0007059

GO:0007094

GO:0007163

GO:0012501

GO:0023052

GO:0030163

GO:0033597

GO:0036211

GO:0042177

GO:0042802

GO:0042803

GO:0043066

GO:0043226

GO:0044615

GO:0045930

GO:0048471

GO:0051301

GO:0051660

GO:0072686

GO:0090267

GO:0140014

GO:1904667

GO:1990728

HMNXSV003035103

Hs.44380.0.A1_3p_at

Hs2.79078.2.S1_3p_s_at

ILMN_1777564

ILMN_2112460

TC04001507.hg

U65410_at

g6466452_3p_s_at

Participates

as a component of

as an input of

MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)

Other forms of this molecule

Activated MAD2L1 [cytosol]

Inferred To

Mad2l1 [cytosol] (Mus musculus)

Mad2l1 [cytosol] (Rattus norvegicus)

mad2l1-1 [cytosol] (Dictyostelium discoideum)

MAD2L1 [cytosol] (Bos taurus)

MAD2L1 [cytosol] (Canis familiaris)

MAD2L1 [cytosol] (Gallus gallus)

MAD2L1 [cytosol] (Sus scrofa)

mdf-2 [cytosol] (Caenorhabditis elegans)

MAD2 [cytosol] (Saccharomyces cerevisiae)

mad2 [cytosol] (Drosophila melanogaster)

mad2 [cytosol] (Schizosaccharomyces pombe)

mad2l1 [cytosol] (Danio rerio)

mad2l1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002349.1

OpenTargets

ENSG00000164109

GeneCards

Q13257

HPA

ENSG00000164109-MAD2L1

Ensembl

ENST00000333047, ENSP00000332295, ENSP00000296509, ENSG00000164109, ENST00000296509

PRO

Q13257

Pharos - Targets

Q13257

PDB

1GO4, 3GMH, 2V64, 2QYF, 1DUJ, 5KHU, 5LCW, 6TLJ, 1KLQ, 1S2H, 2VFX, 6F0X

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.982	38
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.982	50
UniProt:Q15013 MD2BP			0.961	20
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.914	10
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.905	14
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.889	9
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.831	8
UniProt:Q9Y3Q8 T22D4			0.801	8
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.731	11
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [nucleoplasm] (R-HSA-174115) ANAPC4 [cytosol] (R-HSA-174168)	0.725	7
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.701	4
IntAct:EBI-1563533 MAD2 PEPTIDE			0.667	3
UniProt:Q7L775 EPMIP			0.666	4
UniProt:P78536 ADAM17	6	ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763) ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [plasma membrane] (R-HSA-179878)	0.581	3
UniProt:Q8BGZ4	2	Cdc23 [nucleoplasm] (R-MMU-174228) Cdc23 [cytosol] (R-MMU-174137)	0.564	2
UniProt:Q9DCX1 MD2BP			0.564	2
UniProt:Q8R349	2	Cdc16 [nucleoplasm] (R-MMU-174049) Cdc16 [cytosol] (R-MMU-174156)	0.564	2
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P06213-2 INSR			0.556	3
UniProt:O75140-2 DEPDC5			0.556	3
IntAct:EBI-25890541 CCSB			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q13042 CDC16	2	CDC16 [nucleoplasm] (R-HSA-174049) CDC16 [cytosol] (R-HSA-174156)	0.527	3
UniProt:Q9Y2K7 KDM2A	1	KDM2A [nucleoplasm] (R-HSA-3214392)	0.527	3
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	2
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.527	2
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.527	2
UniProt:O95235 KIF20A	3	KIF20A [cytosol] (R-HSA-1015868) p-S528-KIF20A [nucleoplasm] (R-HSA-156685) KIF20A [nucleoplasm] (R-HSA-156721)	0.527	2

Cite Us!