PAOX:FAD oxidises NASPN to SPM

Stable Identifier
R-HSA-141351
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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PAOX:FAD oxidises NASPN to SPM
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Acetylated spermine (NASPN) is oxidised by the flavoenzyme polyamine oxidase (PAOX, woth FAD as cofactor) to produce spermidine (SPM). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).

Literature References
PubMed ID Title Journal Year
12477380 Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion

Diegelman, P, Vujcic, S, Kramer, DL, Porter, CW, Liang, P

Biochem J 2003
Participants
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Output
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as an event of
Catalyst Activity

N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity of PAOX:FAD [peroxisomal matrix]

Physical Entity
PAOX:FAD [peroxisomal matrix] (Homo sapiens)
Activity
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity (GO:0052904)
Orthologous Events
PAOX:FAD oxidises NASPN to SPM (Bos taurus)
PAOX:FAD oxidises NASPN to SPM (Caenorhabditis elegans)
PAOX:FAD oxidises NASPN to SPM (Danio rerio)
PAOX:FAD oxidises NASPN to SPM (Drosophila melanogaster)
PAOX:FAD oxidises NASPN to SPM (Gallus gallus)
PAOX:FAD oxidises NASPN to SPM (Mus musculus)
PAOX:FAD oxidises NASPN to SPM (Rattus norvegicus)
PAOX:FAD oxidises NASPN to SPM (Sus scrofa)
PAOX:FAD oxidises NASPN to SPM (Xenopus tropicalis)
Cross References
Rhea
Authored
Gopinathrao, G  (2008-05-21)
Reviewed
D'Eustachio, P  (2008-06-12)
Created
Jassal, B  (2004-09-16)
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