Reactome | PAOX:FAD oxidises NASPN to SPM

PAOX:FAD oxidises NASPN to SPM

Stable Identifier

R-HSA-141351

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Amine Oxidase reactions (Homo sapiens)
      - PAOs oxidise polyamines to amines (Homo sapiens)
        
        PAOX:FAD oxidises NASPN to SPM (Homo sapiens)
- Metabolism of amino acids and derivatives (Homo sapiens)
  - Metabolism of polyamines (Homo sapiens)
    - Interconversion of polyamines (Homo sapiens)
      - PAOX:FAD oxidises NASPN to SPM (Homo sapiens)

General

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Acetylated spermine (NASPN) is oxidised by the flavoenzyme polyamine oxidase (PAOX, woth FAD as cofactor) to produce spermidine (SPM). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12477380	Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion Vujcic, S, Liang, P, Diegelman, P, Kramer, DL, Porter, CW	Biochem J	2003