Reactome | Trimerization of TRAIL:TRAIL receptor complex

Trimerization of TRAIL:TRAIL receptor complex

Stable Identifier

R-HSA-141139

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Trimerization of TNFSF10:TNFRSF10A,TNFRSF10B, Trimerization of TNFSF10:DR4,DR5

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Trimerization of TRAIL:TRAIL receptor complex

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The complex of TRAIL (TNFSF10) and TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) trimerizes (Sprick et al. 2000, Reis et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
10894160	FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH	Immunity	2000
20852190	Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors Reis, CR, van Assen, AH, Cool, RH, Quax, WJ	Mol. Cell Proteomics	2011