Reactome | Trimerization of TRAIL:TRAIL receptor complex

Trimerization of TRAIL:TRAIL receptor complex

Stable Identifier

R-HSA-141139

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Trimerization of TNFSF10:TNFRSF10A,TNFRSF10B, Trimerization of TNFSF10:DR4,DR5

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Trimerization of TRAIL:TRAIL receptor complex

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The complex of TRAIL (TNFSF10) and TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) trimerizes (Sprick et al. 2000, Reis et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20852190	Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors Reis, CR, van Assen, AH, Quax, WJ, Cool, RH	Mol. Cell Proteomics	2011
10894160	FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H	Immunity	2000