Reactome | Trimerization of TRAIL:TRAIL receptor complex

Trimerization of TRAIL:TRAIL receptor complex

Stable Identifier

R-HSA-141139

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Trimerization of TNFSF10:TNFRSF10A,TNFRSF10B, Trimerization of TNFSF10:DR4,DR5

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Trimerization of TRAIL:TRAIL receptor complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex of TRAIL (TNFSF10) and TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) trimerizes (Sprick et al. 2000, Reis et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
10894160	FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H	Immunity	2000
20852190	Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors Reis, CR, van Assen, AH, Quax, WJ, Cool, RH	Mol. Cell Proteomics	2011