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thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators
Stable Identifier
R-HSA-140872
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The same conformational change that traps thrombin in its complex with cleaved antithrombin III also decreases the affinity of the latter for heparin, and the complex of cleaved antithrombin III and thrombin dissociates from the cell-bound heparin molecule.
Literature References
PubMed ID
Title
Journal
Year
12907439
Heparin-induced substrate behavior of antithrombin Cambridge II
Huntington, JA
,
Carrell, RW
,
Zhou, A
,
Mushunje, A
Blood
2003
Participants
Input
thrombin:cleaved SERPINC1:SERPINC1 activators [plasma membrane]
(Homo sapiens)
Output
SERPINC1 activators [plasma membrane]
thrombin:cleaved SERPINC1 [extracellular region]
(Homo sapiens)
Participates
as an event of
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Orthologous Events
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Xenopus tropicalis)
Authored
D'Eustachio, P (2004-08-24)
Created
D'Eustachio, P (2004-08-24)
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