thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin

Stable Identifier
R-HSA-140870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Antithrombin III in the complex is cleaved by thrombin, thereupon undergoing a conformational change that stabilizes the thrombin:antithrombin III complex, trapping and inactivating the thrombin moiety.
Literature References
PubMed ID Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II

Mushunje, A, Zhou, A, Carrell, RW, Huntington, JA

Blood 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of thrombin:SERPINC1:SERPINC1 activators [plasma membrane]

Physical Entity
thrombin:SERPINC1:SERPINC1 activators [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
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