Antithrombin III in the complex is cleaved by thrombin, thereupon undergoing a conformational change that stabilizes the thrombin:antithrombin III complex, trapping and inactivating the thrombin moiety.
Huntington, JA, Carrell, RW, Zhou, A, Mushunje, A
serine-type endopeptidase activity of thrombin:SERPINC1:SERPINC1 activators [plasma membrane]
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