thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin

Stable Identifier
R-HSA-140870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
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Antithrombin III in the complex is cleaved by thrombin, thereupon undergoing a conformational change that stabilizes the thrombin:antithrombin III complex, trapping and inactivating the thrombin moiety.

Literature References
PubMed ID Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II

Mushunje, A, Zhou, A, Carrell, RW, Huntington, JA

Blood 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of thrombin:SERPINC1:SERPINC1 activators [plasma membrane]

Physical Entity
thrombin:SERPINC1:SERPINC1 activators [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Caenorhabditis elegans)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
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