fibrin multimer -> fibrin multimer, crosslinked + NH4+

Stable Identifier
R-HSA-140851
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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fibrin multimer -> fibrin multimer, crosslinked + NH4+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Fibrin multimers are stabilized by the formation of multiple covalent crosslinks between the side chains of specific lysine and glutamine residues in fibrinogen alpha and gamma chains, catalyzed by factor XIIIa.
Literature References
PubMed ID Title Journal Year
  The Molecular Genetics of Haemostasis and Its Inherited Disorders

Cooper, DN, Tuddenham, EG

  1994
27363989 Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action

Dodt, J, Biswas, A, Oldenburg, J, Philippou, H, Hethershaw, E, Ivaskevicius, V, Ensikat, HJ, Thomas, A

Hum Mutat 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein-glutamine gamma-glutamyltransferase activity of factor XIIIa [extracellular region]

Physical Entity
factor XIIIa [extracellular region] (Homo sapiens)
Activity
protein-glutamine gamma-glutamyltransferase activity (GO:0003810)
Orthologous Events
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Gallus gallus)
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Sus scrofa)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
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