Reactome | n fibrin monomers -> fibrin multimer

n fibrin monomers -> fibrin multimer

Stable Identifier

R-HSA-140842

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Fibrin monomers rapidly and spontaneously associate into large multimers, binding to one another via sites created by fibrinopeptide release (Laudano and Doolittelle 1980). The process of multimerization, and the range of multimer structures that can form in vivo and in vitro, have been studied in detail (Doolittle 1984). Here, multimer size has arbitrarily been set to three fibrin monomers.

Literature References

PubMed ID	Title	Journal	Year
7356959	Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. Doolittle, RF, Laudano, AP	Biochemistry	1980