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TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa
Stable Identifier
R-HSA-140825
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
Synonyms
Inactivation of factor VIIa by TFPI
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TFPI binds to the factor VIIa:TF complex and to factor Xa at the endothelial surface, forming a stable heterotetrameric complex in which factor VIIa is catalytically inactive.
Literature References
PubMed ID
Title
Journal
Year
2271516
Regulation of coagulation by a multivalent Kunitz-type inhibitor
Novotny, WF
,
Girard, TJ
,
Broze, GJ Jr
Biochemistry
1990
Participants
Input
factor Xa [extracellular region]
(Homo sapiens)
TF:F7a [plasma membrane]
(Homo sapiens)
TFPI [extracellular region]
(Homo sapiens)
Output
TFPI:TF:F7a:factor Xa [plasma membrane]
(Homo sapiens)
Participates
as an event of
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
Event Information
Go Biological Process
negative regulation of blood coagulation, extrinsic pathway (2000264)
Orthologous Events
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Canis familiaris)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Sus scrofa)
Authored
D'Eustachio, P (2004-08-24)
Created
D'Eustachio, P (2004-08-24)
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