TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa

Stable Identifier
R-HSA-140825
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Inactivation of factor VIIa by TFPI
ReviewStatus
5/5
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TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa
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TFPI binds to the factor VIIa:TF complex and to factor Xa at the endothelial surface, forming a stable heterotetrameric complex in which factor VIIa is catalytically inactive.

Literature References
PubMed ID Title Journal Year
2271516 Regulation of coagulation by a multivalent Kunitz-type inhibitor

Novotny, WF, Girard, TJ, Broze, GJ Jr

Biochemistry 1990
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of blood coagulation, extrinsic pathway (2000264)
Orthologous Events
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Danio rerio)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Sus scrofa)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
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