TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa

Stable Identifier
R-HSA-140825
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Inactivation of factor VIIa by TFPI
Locations in the PathwayBrowser
Summation

TFPI binds to the factor VIIa:TF complex and to factor Xa at the endothelial surface, forming a stable heterotetrameric complex in which factor VIIa is catalytically inactive.

Literature References
PubMed ID Title Journal Year
2271516 Regulation of coagulation by a multivalent Kunitz-type inhibitor

Broze, GJ Jr, Girard, TJ, Novotny, WF

Biochemistry 1990
Participants
Participant Of
Orthologous Events
Authored