factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)

Stable Identifier
R-HSA-140823
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
activation of factor IX (TF:F7a catalyst)
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factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)
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Factor VIIa, bound to tissue factor at the endothelial cell surface, catalyzes the formation of activated factor IX with high efficiency. The amino terminal part of the heavy chain of factor IX, the factor IX activation peptide, is released. (This peptide has no known function.)

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of TF:F7a [plasma membrane]
Physical Entity
TF:F7a [plasma membrane]
Activity
serine-type endopeptidase activity (0004252)
Orthologous Events
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)