Reactome | SERPINC1 [extracellular region]

SERPINC1 [extracellular region]

Stable Identifier

R-HSA-140807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

antithrombin III, Antithrombin-III, Antithrombin-3, AT3

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
6298709	Cloning and expression of the cDNA for human antithrombin III Wion, KL, Vehar, GA, Lawn, RM	Nucleic Acids Res	1982

External Reference Information

External Reference

UniProt:P01008 SERPINC1

Gene Names

SERPINC1, AT3, PRO0309

Chain

signal peptide:1-32, chain:33-464

Reference Genes

BioGPS Gene:462 SERPINC1

COSMIC (genes):SERPINC1 SERPINC1

CTD Gene:462 SERPINC1

dbSNP Gene:462 SERPINC1

ENSEMBL:ENSG00000117601 SERPINC1

HGNC:775 SERPINC1

KEGG Gene (Homo sapiens):462 SERPINC1

Monarch:462 SERPINC1

NCBI Gene:462 SERPINC1

OMIM:107300 SERPINC1

UCSC:P01008 SERPINC1

Reference Transcript

RefSeq:NM_000488.3 SERPINC1

Other Identifiers

0001500672

11723252_a_at

1554491_3p_a_at

1554491_a_at

16696535

210049_at

2444530

2444531

2444532

2444535

2444536

2444538

2444539

2444540

2444541

2444548

2444549

37175_at

462

7922420

A_23_P114626

GE60489

GO:0002020

GO:0002376

GO:0002438

GO:0003674

GO:0004867

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005886

GO:0006464

GO:0006810

GO:0006950

GO:0007584

GO:0007595

GO:0007596

GO:0007599

GO:0008150

GO:0008201

GO:0010466

GO:0010951

GO:0019899

GO:0030193

GO:0030234

GO:0030414

GO:0031012

GO:0042802

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0048856

GO:0062023

GO:0070062

GO:0072562

GO:2000266

Hs2.75599.2.S1_3p_at

Hs2.75599.2.S1_3p_s_at

ILMN_1762605

L00190_s_at

M21642_at

M21642_s_at

PH_hs_0004345

PH_hs_0040357

TC01003535.hg

g576553_3p_at

g576553_3p_x_at

Participant Of

input

antithrombin III + heparin -> antithrombin III:heparin

Other forms of this molecule

SERPINC1(33-425) [plasma membrane]

SERPINC1(426-464) [plasma membrane]

SERPINC1 [plasma membrane]

SERPINC1(33-425) [extracellular region]

SERPINC1(426-464) [extracellular region]

p-SERPINC1 [endoplasmic reticulum lumen]

SERPINC1 [endoplasmic reticulum lumen]

Inferred To

Spn42Da [extracellular region] (Drosophila melanogaster)

srp-6 [extracellular region] (Caenorhabditis elegans)

Spn28Dc [extracellular region] (Drosophila melanogaster)

Spn28Da [extracellular region] (Drosophila melanogaster)

Spn77Bc [extracellular region] (Drosophila melanogaster)

Homologues of SERPINC1 [extracellular region] (Caenorhabditis elegans)

Homologues of SERPINC1 [extracellular region] (Drosophila melanogaster)

Spn88Eb [extracellular region] (Drosophila melanogaster)

Spn27A [extracellular region] (Drosophila melanogaster)

srp-2 [extracellular region] (Caenorhabditis elegans)

Spn77Ba [extracellular region] (Drosophila melanogaster)

Acp76A [extracellular region] (Drosophila melanogaster)

Spn100A [extracellular region] (Drosophila melanogaster)

Spn42Dd [extracellular region] (Drosophila melanogaster)

SERPINC1 [extracellular region] (Caenorhabditis elegans)

SERPINC1 [extracellular region] (Canis familiaris)

SERPINC1 [extracellular region] (Sus scrofa)

srp-8 [extracellular region] (Caenorhabditis elegans)

Spn43Aa [extracellular region] (Drosophila melanogaster)

Spn47C [extracellular region] (Drosophila melanogaster)

serpinc1 [extracellular region] (Danio rerio)

serpinc1 [extracellular region] (Xenopus tropicalis)

Dmel\CG43366 [extracellular region] (Drosophila melanogaster)

srp-7 [extracellular region] (Caenorhabditis elegans)

Spn42Db [extracellular region] (Drosophila melanogaster)

Spn75F [extracellular region] (Drosophila melanogaster)

Serpinc1 [extracellular region] (Mus musculus)

Serpinc1 [extracellular region] (Rattus norvegicus)

Spn28Db [extracellular region] (Drosophila melanogaster)

Spn55B [extracellular region] (Drosophila melanogaster)

nec [extracellular region] (Drosophila melanogaster)

Spn31A [extracellular region] (Drosophila melanogaster)

Spn43Ab [extracellular region] (Drosophila melanogaster)

Spn53F [extracellular region] (Drosophila melanogaster)

Spn88Ea [extracellular region] (Drosophila melanogaster)

srp-1 [extracellular region] (Caenorhabditis elegans)

Spn38F [extracellular region] (Drosophila melanogaster)

Spn77Bb [extracellular region] (Drosophila melanogaster)

srp-3 [extracellular region] (Caenorhabditis elegans)

Spn42De [extracellular region] (Drosophila melanogaster)

Spn28B [extracellular region] (Drosophila melanogaster)

Spn85F [extracellular region] (Drosophila melanogaster)

Spn28F [extracellular region] (Drosophila melanogaster)

Spn43Ad [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_000479.1

OpenTargets

ENSG00000117601

HPA

ENSG00000117601-SERPINC1

GeneCards

P01008

ZINC - Substances

ANT3_HUMAN

ZINC target

P01008

Ensembl

ENSP00000356671, ENST00000367698, ENSG00000117601

PRO

P01008

ZINC - Predictions - Purchasable

ANT3_HUMAN

Orphanet

15272

HMDB Protein

HMDBP01724

PDB

1JVQ, 1E03, 1E05, 1E04, 1SR5, 1ANT, 2B5T, 2GD4, 4EB1, 2B4X, 1R1L, 1NQ9, 1LK6, 2ZNH, 2BEH, 1T1F, 1TB6, 1OYH, 1BR8, 2ANT, 2HIJ, 1AZX, 1ATH, 1DZH, 3EVJ, 1DZG, 3KCG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01008 SERPINC1	8	SERPINC1(426-464) [plasma membrane] (R-HSA-140816) SERPINC1(33-425) [plasma membrane] (R-HSA-140815) SERPINC1 [plasma membrane] (R-HSA-140792) SERPINC1 [extracellular region] (R-HSA-140807) SERPINC1(33-425) [extracellular region] (R-HSA-140814) SERPINC1(426-464) [extracellular region] (R-HSA-140817) p-SERPINC1 [endoplasmic reticulum lumen] (R-HSA-8957069) SERPINC1 [endoplasmic reticulum lumen] (R-HSA-8956773)	0.558	2
UniProt:Q07021 C1QBP	3	C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123) C1QBP [cytosol] (R-HSA-9645690)	0.462	3

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