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SERPINC1 [extracellular region]
Stable Identifier
R-HSA-140807
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
antithrombin III, Antithrombin-III, Antithrombin-3, AT3
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
SERPINC1 binds SERPINC1 activators (Homo sapiens)
SERPINC1 [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
6298709
Cloning and expression of the cDNA for human antithrombin III
Lawn, RM
,
Vehar, GA
,
Wion, KL
Nucleic Acids Res
1982
External Reference Information
External Reference
UniProt:P01008 SERPINC1
Gene Names
SERPINC1, AT3, PRO0309
Chain
signal peptide:1-32, chain:33-464
Reference Genes
BioGPS Gene:462 SERPINC1
COSMIC (genes):SERPINC1 SERPINC1
CTD Gene:462 SERPINC1
dbSNP Gene:462 SERPINC1
ENSEMBL:ENSG00000117601 SERPINC1
ENSEMBL_homo_sapiens_GENE:ENSG00000117601.15 SERPINC1
HGNC:775 SERPINC1
KEGG Gene (Homo sapiens):462 SERPINC1
Monarch:462 SERPINC1
NCBI Gene:462 SERPINC1
OMIM:107300 SERPINC1
UCSC:P01008 SERPINC1
Reference Transcript
RefSeq:NM_000488.3 SERPINC1
Other Identifiers
11723252_a_at
1554491_3p_a_at
1554491_PM_a_at
1554491_a_at
16696535
210049_PM_at
210049_at
2444530
2444531
2444532
2444535
2444536
2444538
2444539
2444540
2444541
2444548
2444549
37175_at
462
7922420
A_23_P114626
GE60489
GO:0002020
GO:0004867
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005886
GO:0007596
GO:0007599
GO:0008201
GO:0030193
GO:0030312
GO:0030414
GO:0031012
GO:0042060
GO:0042802
GO:0043226
GO:0062023
GO:0070062
GO:0072562
GO:0098772
HMNXSV003015800
Hs2.75599.2.S1_3p_at
Hs2.75599.2.S1_3p_s_at
ILMN_1762605
L00190_s_at
M21642_at
M21642_s_at
PH_hs_0004345
PH_hs_0040357
TC01003535.hg
g576553_3p_at
g576553_3p_x_at
Participates
as an input of
SERPINC1 binds SERPINC1 activators (Homo sapiens)
Other forms of this molecule
SERPINC1(33-425) [plasma membrane]
SERPINC1(426-464) [plasma membrane]
SERPINC1 [plasma membrane]
SERPINC1(33-425) [extracellular region]
SERPINC1(426-464) [extracellular region]
p-SERPINC1 [endoplasmic reticulum lumen]
SERPINC1 [endoplasmic reticulum lumen]
Inferred To
Spn42Da [extracellular region]
(Drosophila melanogaster)
srp-6 [extracellular region]
(Caenorhabditis elegans)
Spn28Da [extracellular region]
(Drosophila melanogaster)
Homologues of SERPINC1 [extracellular region]
(Caenorhabditis elegans)
Homologues of SERPINC1 [extracellular region]
(Drosophila melanogaster)
Spn88Eb [extracellular region]
(Drosophila melanogaster)
Spn27A [extracellular region]
(Drosophila melanogaster)
srp-2 [extracellular region]
(Caenorhabditis elegans)
Acp76A [extracellular region]
(Drosophila melanogaster)
Spn100A [extracellular region]
(Drosophila melanogaster)
Spn42Dd [extracellular region]
(Drosophila melanogaster)
SERPINC1 [extracellular region]
(Bos taurus)
SERPINC1 [extracellular region]
(Caenorhabditis elegans)
SERPINC1 [extracellular region]
(Canis familiaris)
SERPINC1 [extracellular region]
(Gallus gallus)
SERPINC1 [extracellular region]
(Mus musculus)
SERPINC1 [extracellular region]
(Sus scrofa)
srp-8 [extracellular region]
(Caenorhabditis elegans)
Spn43Aa [extracellular region]
(Drosophila melanogaster)
Spn47C [extracellular region]
(Drosophila melanogaster)
serpinc1 [extracellular region]
(Danio rerio)
serpinc1 [extracellular region]
(Xenopus tropicalis)
Dmel\CG43366 [extracellular region]
(Drosophila melanogaster)
srp-7 [extracellular region]
(Caenorhabditis elegans)
Spn42Db [extracellular region]
(Drosophila melanogaster)
Spn75F [extracellular region]
(Drosophila melanogaster)
Serpinc1 [extracellular region]
(Rattus norvegicus)
Spn28Db [extracellular region]
(Drosophila melanogaster)
Spn55B [extracellular region]
(Drosophila melanogaster)
nec [extracellular region]
(Drosophila melanogaster)
Spn31A [extracellular region]
(Drosophila melanogaster)
Spn43Ab [extracellular region]
(Drosophila melanogaster)
Spn53F [extracellular region]
(Drosophila melanogaster)
Spn88Ea [extracellular region]
(Drosophila melanogaster)
srp-1 [extracellular region]
(Caenorhabditis elegans)
Spn38F [extracellular region]
(Drosophila melanogaster)
srp-3 [extracellular region]
(Caenorhabditis elegans)
Spn42Dc [extracellular region]
(Drosophila melanogaster)
Spn42De [extracellular region]
(Drosophila melanogaster)
Spn28B [extracellular region]
(Drosophila melanogaster)
Spn85F [extracellular region]
(Drosophila melanogaster)
Spn28F [extracellular region]
(Drosophila melanogaster)
Spn43Ad [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000479.1
Guide to Pharmacology - Targets
2632
OpenTargets
ENSG00000117601
ZINC - Substances
ANT3_HUMAN
ZINC target
P01008
PRO
P01008
PDB
1TB6
,
1E03
,
1OYH
,
2B4X
,
1E04
,
1ATH
,
1BR8
,
1JVQ
,
1ANT
,
1E05
,
1DZG
,
1AZX
,
2ZNH
,
4EB1
,
2BEH
,
3EVJ
,
1SR5
,
3KCG
,
1DZH
,
2B5T
,
1LK6
,
2ANT
,
2HIJ
,
1R1L
,
2GD4
,
1NQ9
,
1T1F
HPA
ENSG00000117601-SERPINC1
GeneCards
P01008
Ensembl
ENSP00000356671
,
ENSG00000117601
,
ENST00000367698
Pharos - Targets
P01008
Orphanet
15272
ZINC - Predictions - Purchasable
ANT3_HUMAN
HMDB Protein
HMDBP01724
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01008 SERPINC1
8
SERPINC1(33-425) [plasma membrane]
(R-HSA-140815)
SERPINC1(426-464) [plasma membrane]
(R-HSA-140816)
SERPINC1 [plasma membrane]
(R-HSA-140792)
SERPINC1 [extracellular region]
(R-HSA-140807)
SERPINC1(33-425) [extracellular region]
(R-HSA-140814)
SERPINC1(426-464) [extracellular region]
(R-HSA-140817)
p-SERPINC1 [endoplasmic reticulum lumen]
(R-HSA-8957069)
SERPINC1 [endoplasmic reticulum lumen]
(R-HSA-8956773)
0.558
2
UniProt:Q9BXT5 TEX15
1
TEX15 [nucleoplasm]
(R-HSA-914159)
0.527
2
UniProt:Q9H8H2 DDX31
0.527
2
UniProt:P43251 BTD
13
BTD R79C [mitochondrial matrix]
(R-HSA-4225085)
BTD Q456H [mitochondrial matrix]
(R-HSA-4225082)
BTD C33Ffs*36 [mitochondrial matrix]
(R-HSA-4225081)
BTD A171T [mitochondrial matrix]
(R-HSA-4225080)
BTD G34S [mitochondrial matrix]
(R-HSA-4225079)
BTD R538C [mitochondrial matrix]
(R-HSA-4225078)
BTD R79C [extracellular region]
(R-HSA-3325545)
BTD A171T [extracellular region]
(R-HSA-3325576)
BTD R538C [extracellular region]
(R-HSA-3325543)
BTD Q456H [extracellular region]
(R-HSA-3325552)
BTD C33Ffs*36 [extracellular region]
(R-HSA-3325555)
BTD [mitochondrial matrix]
(R-HSA-4167525)
BTD [extracellular region]
(R-HSA-3076888)
0.527
3
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P55899 FCGRN
0.527
2
UniProt:P53597 SUCLG1
1
SUCLG1 [mitochondrial matrix]
(R-HSA-156623)
0.527
3
UniProt:Q9H4B7 TUBB1
6
TUBB1 folding intermediate [cytosol]
(R-HSA-392793)
TUBB1 unfolded [cytosol]
(R-HSA-392782)
Polyglycyl-TUBB1 [cytosol]
(R-HSA-8867450)
Polyglutamyl-TUBB1 [cytosol]
(R-HSA-8867413)
TUBB1 [axonemal microtubule]
(R-HSA-5610437)
TUBB1 [cytosol]
(R-HSA-191703)
0.527
2
UniProt:Q07021 C1QBP
3
C1QBP [cytosol]
(R-HSA-9645690)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [plasma membrane]
(R-HSA-158123)
0.462
3
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