Reactome | factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

Stable Identifier

R-HSA-140777

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

activation of factor X by TF:F7

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Factor VII, bound to tissue factor at the endothelial cell surface, catalyzes the activation of factor X from plasma with moderate efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)

Literature References

PubMed ID	Title	Journal	Year
3275472	Tissue factor and hemostasis Nemerson, Y	Blood	1988
3527261	Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine Bach, R, Gentry, R, Nemerson, Y	Biochemistry	1986
6980899	Binding of human factor VII and VIIa to monocytes Broze, GJ Jr	J Clin Invest	1982