factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

Stable Identifier
R-HSA-140777
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
activation of factor X by TF:F7
Locations in the PathwayBrowser
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Factor VII, bound to tissue factor at the endothelial cell surface, catalyzes the activation of factor X from plasma with moderate efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)

Literature References
PubMed ID Title Journal Year
3527261 Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine

Bach, R, Gentry, R, Nemerson, Y

Biochemistry 1986
3275472 Tissue factor and hemostasis

Nemerson, Y

Blood 1988
6980899 Binding of human factor VII and VIIa to monocytes

Broze, GJ Jr

J Clin Invest 1982
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of TF:F7 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created