Factor VIIa, bound to tissue factor at the endothelial cell surface (the "extrinsic tenase complex"), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)
Rao, LV, Rapaport, SI
Kisiel, W, Pedersen, AH, Komiyama, Y
Broze, GJ Jr
serine-type endopeptidase activity of TF:F7a [plasma membrane]
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