factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)

Stable Identifier
R-HSA-140736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
activation of factor X by TF:F7a
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Factor VIIa, bound to tissue factor at the endothelial cell surface (the "extrinsic tenase complex"), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)

Literature References
PubMed ID Title Journal Year
2248955 Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor

Komiyama, Y, Pedersen, AH, Kisiel, W

Biochemistry 1990
8578528 The tissue factor pathway: how it has become a "prima ballerina"

Rapaport, SI, Rao, LV

Thromb Haemost 1995
6980899 Binding of human factor VII and VIIa to monocytes

Broze, GJ Jr

J Clin Invest 1982
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of TF:F7a [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created