factor V -> factor Va + factor V activation peptide

Stable Identifier
R-HSA-140696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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factor V -> factor Va + factor V activation peptide
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated thrombin (factor IIa) catalyzes the conversion of factor V to factor Va (activated factor V). The activation peptide released in this reaction has no known function.
Literature References
PubMed ID Title Journal Year
14982929 The factor V activation paradox

Butenas, S, Xu, H, Orfeo, T, Nesheim, ME, Brufatto, N, Mann, KG

J Biol Chem 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]

Physical Entity
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
This event is regulated
Negatively by
Regulator
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
Regulator
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
Orthologous Events
factor V -> factor Va + factor V activation peptide (Bos taurus)
factor V -> factor Va + factor V activation peptide (Canis familiaris)
factor V -> factor Va + factor V activation peptide (Gallus gallus)
factor V -> factor Va + factor V activation peptide (Mus musculus)
factor V -> factor Va + factor V activation peptide (Sus scrofa)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
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