factor V -> factor Va + factor V activation peptide

Stable Identifier
R-HSA-140696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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factor V -> factor Va + factor V activation peptide
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Activated thrombin (factor IIa) catalyzes the conversion of factor V to factor Va (activated factor V). The activation peptide released in this reaction has no known function.

Literature References
PubMed ID Title Journal Year
14982929 The factor V activation paradox

Orfeo, T, Brufatto, N, Nesheim, ME, Xu, H, Butenas, S, Mann, KG

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
Physical Entity
activated thrombin (factor IIa) [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
This event is regulated
Negatively by
Orthologous Events
factor V -> factor Va + factor V activation peptide (Bos taurus)
factor V -> factor Va + factor V activation peptide (Canis familiaris)
factor V -> factor Va + factor V activation peptide (Danio rerio)
factor V -> factor Va + factor V activation peptide (Gallus gallus)
factor V -> factor Va + factor V activation peptide (Mus musculus)
factor V -> factor Va + factor V activation peptide (Sus scrofa)
factor V -> factor Va + factor V activation peptide (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)