factor V -> factor Va + factor V activation peptide

Stable Identifier
R-HSA-140696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
factor V -> factor Va + factor V activation peptide
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated thrombin (factor IIa) catalyzes the conversion of factor V to factor Va (activated factor V). The activation peptide released in this reaction has no known function.

Literature References
PubMed ID Title Journal Year
14982929 The factor V activation paradox

Butenas, S, Xu, H, Orfeo, T, Nesheim, ME, Brufatto, N, Mann, KG

J Biol Chem 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]

Physical Entity
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
This event is regulated
Negatively by
Regulator
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
Regulator
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
Orthologous Events
factor V -> factor Va + factor V activation peptide (Bos taurus)
factor V -> factor Va + factor V activation peptide (Canis familiaris)
factor V -> factor Va + factor V activation peptide (Danio rerio)
factor V -> factor Va + factor V activation peptide (Gallus gallus)
factor V -> factor Va + factor V activation peptide (Mus musculus)
factor V -> factor Va + factor V activation peptide (Sus scrofa)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
Cite Us!