prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The membrane-bound Va:Xa (prothrombinase) complex rapidly activates large amounts of thrombin. Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process (Mann et al. 1988, Orfeo et al. 2004). Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') and used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014).

Literature References
PubMed ID Title Journal Year
3052293 Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

Mann, KG, Jenny, RJ, Krishnaswamy, S

Annu Rev Biochem 1988
14982929 The factor V activation paradox

Orfeo, T, Brufatto, N, Nesheim, ME, Xu, H, Butenas, S, Mann, KG

J Biol Chem 2004
Participant Of
Catalyst Activity
Catalyst Activity
serine-type endopeptidase activity of Va:Xa [plasma membrane]
Physical Entity
This event is regulated
Orthologous Events
Cite Us!