Reactome | prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

Stable Identifier

R-HSA-140664

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

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The membrane-bound Va:Xa (prothrombinase) complex rapidly activates large amounts of thrombin. Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process (Mann et al. 1988, Orfeo et al. 2004). Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') and used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
3052293	Cofactor proteins in the assembly and expression of blood clotting enzyme complexes Mann, KG, Jenny, RJ, Krishnaswamy, S	Annu Rev Biochem	1988
14982929	The factor V activation paradox Orfeo, T, Brufatto, N, Nesheim, ME, Xu, H, Butenas, S, Mann, KG	J Biol Chem	2004