Translocation of PMAIP1 (NOXA) to mitochondria

Stable Identifier
R-HSA-140216
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Translocation of PMAIP1 (NOXA) to mitochondria
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
It was observed that cytosolic Noxa underwent BH3 motif-dependent localization to mitochondria and interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9.
Literature References
PubMed ID Title Journal Year
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N

Science 2000
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein insertion into mitochondrial membrane (0051204)
Orthologous Events
Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)
Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)
Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)
Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)
Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)
Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)
Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)
Authored
Gopinathrao, G  (2004-08-18)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
Cite Us!