Translocation of PMAIP1 (NOXA) to mitochondria

Stable Identifier
R-HSA-140216
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Translocation of PMAIP1 (NOXA) to mitochondria
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It was observed that cytosolic Noxa underwent BH3 motif-dependent localization to mitochondria and interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9.
Literature References
PubMed ID Title Journal Year
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N

Science 2000
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Output
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as an event of
Event Information
Go Biological Process
protein insertion into mitochondrial membrane (0051204)
Orthologous Events
Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)
Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)
Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)
Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)
Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)
Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)
Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)
Authored
Gopinathrao, G  (2004-08-18)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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