Translocation of PMAIP1 (NOXA) to mitochondria

Stable Identifier
R-HSA-140216
Type
Reaction
Species
Homo sapiens
Compartment
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It was observed that cytosolic Noxa underwent BH3 motif-dependent localization to mitochondria and interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9.

Literature References
PubMed ID Title Journal Year
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N

Science 2000
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Event Information
Orthologous Events
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