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PMAIP1 [cytosol]
Stable Identifier
R-HSA-140215
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NOXA protein
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)
PMAIP1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of NOXA and translocation to mitochondria (Homo sapiens)
TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)
PMAIP1 [cytosol] (Homo sapiens)
Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)
PMAIP1 [cytosol] (Homo sapiens)
Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)
PMAIP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13794 PMAIP1
Gene Names
PMAIP1, NOXA
Chain
chain:1-54
Reference Genes
BioGPS Gene:5366 PMAIP1
COSMIC (genes):PMAIP1 PMAIP1
CTD Gene:5366 PMAIP1
dbSNP Gene:5366 PMAIP1
ENSEMBL:ENSG00000141682 PMAIP1
HGNC:9108 PMAIP1
KEGG:hsa:5366 PMAIP1
Monarch:5366 PMAIP1
NCBI Gene:5366 PMAIP1
OMIM:604959 PMAIP1
UCSC:Q13794 PMAIP1
Reference Transcript
RefSeq:NM_021127.2 PMAIP1
Other Identifiers
11724509_a_at
11724510_at
16852683
204285_PM_s_at
204285_s_at
204286_PM_s_at
204286_s_at
3790705
3790706
3790707
3790708
3790709
3790710
3790711
3790712
3790713
41048_at
5366
8021470
A_14_P202176
A_23_P207999
A_33_P3619171
D90070_s_at
GE57443
GO:0001836
GO:0002376
GO:0005515
GO:0005634
GO:0005739
GO:0005741
GO:0005829
GO:0006915
GO:0006919
GO:0006974
GO:0007005
GO:0010498
GO:0010907
GO:0010917
GO:0012501
GO:0030163
GO:0042149
GO:0043029
GO:0043065
GO:0043226
GO:0043280
GO:0043331
GO:0043517
GO:0046902
GO:0051607
GO:0061024
GO:0071456
GO:0072332
GO:0072593
GO:0090200
GO:0097136
GO:0097193
GO:0098542
GO:1902043
GO:1902237
GO:2001244
HMNXSV003013508
Hs.96.0.A1_3p_a_at
ILMN_2098446
PH_hs_0027514
TC18000213.hg
TC18000741.hg
g10863922_3p_a_at
Participates
as an output of
Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)
TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)
as an input of
Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)
Other forms of this molecule
PMAIP1 [mitochondrial outer membrane]
Inferred To
pmaip1 [cytosol]
(Danio rerio)
PMAIP1 [cytosol]
(Bos taurus)
PMAIP1 [cytosol]
(Canis familiaris)
PMAIP1 [cytosol]
(Gallus gallus)
PMAIP1 [cytosol]
(Sus scrofa)
Pmaip1 [cytosol]
(Mus musculus)
Pmaip1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_066950.1
ENSEMBL
ENST00000316660
,
ENST00000269518
,
ENSP00000269518
,
ENSP00000326119
OpenTargets
ENSG00000141682
HPA
ENSG00000141682-PMAIP1
PRO
Q13794
Pharos - Targets
Q13794
PDB
3MQP
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.845
6
UniProt:Q07817-1 BCL2L1
0.683
3
UniProt:Q92843 B2CL2
0.558
2
UniProt:P10415-1 BCL2
0.544
3
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.524
3
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