TP53 stimulates PMAIP1 (NOXA) expression

Stable Identifier
R-HSA-140214
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) stimulates transcription of PMAIP1 (NOXA) (Oda et al. 2000, Li et al. 2004). The complex of TP53 with ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) is likely involved in the transcriptional activation of PMAIP1 (Wang et al. 2012, Wilson et al. 2013).

Literature References
PubMed ID Title Journal Year
15126337 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

Li, CQ, Robles, AI, Hanigan, CL, Hofseth, LJ, Trudel, LJ, Harris, CC, Wogan, GN

Cancer Res 2004
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A

J. Neurosci. 2013
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N

Science 2000
22766503 iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes

Wang, L, Xing, H, Tian, Z, Peng, L, Li, Y, Tang, K, Rao, Q, Wang, M, Wang, J

Biochem. Biophys. Res. Commun. 2012
Participants
Participant Of
This event is regulated
Reviewed
Created