TP53 stimulates PMAIP1 (NOXA) expression

Stable Identifier
R-HSA-140214
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates PMAIP1 (NOXA) expression
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TP53 (p53) stimulates transcription of PMAIP1 (NOXA) (Oda et al. 2000, Li et al. 2004). The complex of TP53 with ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) is likely involved in the transcriptional activation of PMAIP1 (Wang et al. 2012, Wilson et al. 2013).

Literature References
PubMed ID Title Journal Year
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Feinstein, E, Wilson, AM, Morquette, B, Abdouh, M, Bernier, G, Unsain, N, Di Polo, A, Barker, PA

J. Neurosci. 2013
15126337 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

Hanigan, CL, Robles, AI, Trudel, LJ, Hofseth, LJ, Li, CQ, Wogan, GN, Harris, CC

Cancer Res 2004
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N

Science 2000
22766503 iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes

Tang, K, Tian, Z, Wang, L, Xing, H, Peng, L, Rao, Q, Wang, J, Li, Y, Wang, M

Biochem. Biophys. Res. Commun. 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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