Reactome | BAX [mitochondrial outer membrane]

BAX [mitochondrial outer membrane]

Stable Identifier

R-HSA-139949

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Activated BAX inserted into mitochondrial membrane

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD

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External Reference Information

External Reference

UniProt:Q07812 BAX

Gene Names

BAX, BCL2L4

Chain

chain:1-192

Reference Genes

BioGPS Gene:581 BAX

COSMIC (genes):BAX BAX

CTD Gene:581 BAX

dbSNP Gene:581 BAX

ENSEMBL:ENSG00000087088 BAX

ENSEMBL_homo_sapiens_GENE:ENSG00000087088.21 BAX

HGNC:959 BAX

KEGG Gene (Homo sapiens):581 BAX

Monarch:581 BAX

NCBI Gene:581 BAX

OMIM:600040 BAX

UCSC:Q07812 BAX

Reference Transcript

Other Identifiers

11742537_a_at

11759444_x_at

16863922

1997_s_at

1998_i_at

2065_s_at

2066_at

2067_f_at

208478_PM_s_at

208478_s_at

211833_PM_s_at

211833_s_at

3838069

3838070

3838073

3838075

3838076

3838077

3838079

3838080

3838081

3838082

3838083

3838084

3838085

3838086

3838087

3838088

4101422

581

8030158

A_14_P135790

A_23_P208706

A_23_P346309

A_23_P346311

A_33_P3341144

GE498533

GE57679

GO:0001541

GO:0001764

GO:0001776

GO:0001777

GO:0001782

GO:0001783

GO:0001822

GO:0001836

GO:0001974

GO:0002262

GO:0002352

GO:0002358

GO:0002376

GO:0002904

GO:0005215

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005741

GO:0005757

GO:0005783

GO:0005789

GO:0005829

GO:0006629

GO:0006687

GO:0006808

GO:0006886

GO:0006915

GO:0006919

GO:0006950

GO:0006974

GO:0007005

GO:0007281

GO:0007283

GO:0007399

GO:0007548

GO:0008053

GO:0008283

GO:0008285

GO:0008289

GO:0008584

GO:0008625

GO:0008630

GO:0008635

GO:0008637

GO:0009566

GO:0009611

GO:0009636

GO:0009651

GO:0009791

GO:0010212

GO:0010248

GO:0010332

GO:0010524

GO:0010917

GO:0012501

GO:0015267

GO:0016020

GO:0021854

GO:0021987

GO:0022414

GO:0023052

GO:0030154

GO:0030544

GO:0031334

GO:0031966

GO:0032091

GO:0032469

GO:0032471

GO:0032976

GO:0033137

GO:0033599

GO:0034620

GO:0034644

GO:0035108

GO:0035234

GO:0036211

GO:0042475

GO:0042802

GO:0042803

GO:0042981

GO:0043065

GO:0043226

GO:0043523

GO:0043524

GO:0043525

GO:0043653

GO:0045136

GO:0046666

GO:0046930

GO:0046982

GO:0048087

GO:0048147

GO:0048515

GO:0048597

GO:0048678

GO:0048856

GO:0048870

GO:0048872

GO:0048873

GO:0050673

GO:0051087

GO:0051094

GO:0051204

GO:0051209

GO:0051281

GO:0051402

GO:0051434

GO:0051649

GO:0051726

GO:0051881

GO:0055065

GO:0055085

GO:0060011

GO:0060041

GO:0060057

GO:0060058

GO:0060068

GO:0060402

GO:0061024

GO:0065003

GO:0070059

GO:0070062

GO:0070242

GO:0071310

GO:0071944

GO:0072332

GO:0090200

GO:0097049

GO:0097136

GO:0097144

GO:0097145

GO:0097190

GO:0097191

GO:0097192

GO:0097193

GO:0097435

GO:0098586

GO:1900103

GO:1901135

GO:1902108

GO:1902110

GO:1902262

GO:1902263

GO:1902445

GO:1902512

GO:1903896

GO:1904019

GO:1904037

GO:1990117

GO:2000243

GO:2000673

GO:2001233

GO:2001234

GO:2001244

HMNXSV003032285

HMNXSV003044786

ILMN_1683300

ILMN_2258383

ILMN_2321064

PH_hs_0027269

TC19000716.hg

TC19002194.hg

g841237_3p_a_at

Participates

as an output of

as an input of

Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)

as a component of

Activated BAX [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

BAX [cytosol]

BAX activated [cytosol]

Inferred To

baxa [mitochondrial outer membrane] (Danio rerio)

Ghost homologue of BAX [mitochondrial outer membrane] (Xenopus tropicalis)

BAX [mitochondrial outer membrane] (Bos taurus)

BAX [mitochondrial outer membrane] (Canis familiaris)

BAX [mitochondrial outer membrane] (Sus scrofa)

Bax [mitochondrial outer membrane] (Mus musculus)

Bax [mitochondrial outer membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001278357.1, NP_620116.1, NP_004315.1, NP_620119.2, XP_016882566.1, NP_620118.1, NP_001278360.1

OpenTargets

ENSG00000087088

GeneCards

Q07812

ZINC - Substances

BAX_HUMAN

HPA

ENSG00000087088-BAX

ZINC target

Q07812

Ensembl

ENST00000515540, ENST00000293288, ENSG00000087088, ENST00000415969, ENSP00000348871, ENSP00000346461, ENST00000356483, ENSP00000389971, ENSP00000426328, ENSP00000263262, ENSP00000293288, ENST00000354470, ENST00000345358

PRO

Q07812

Pharos - Targets

Q07812

PDB

4ZIE, 4S0P, 4ZIF, 8G1T, 4S0O, 4ZIG, 8SPZ, 2LR1, 2G5B, 7ADT, 8SRY, 4UF2, 3PL7, 5W5Z, 3PK1, 4BD2, 6EB6, 8SVK, 8SRX, 4BDU, 6TRR, 8SPE, 4ZIH, 4BD8, 6XY6, 8SPF, 2K7W, 4BD7, 5W60, 4ZII, 5W5X, 4BD6, 1F16, 6L8V, 5W61, 6L95

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07812 BAX	3	BAX [cytosol] (R-HSA-139916) BAX activated [cytosol] (R-HSA-139907) BAX [mitochondrial outer membrane] (R-HSA-139949)	0.975	29
UniProt:Q07817-1 BCL2L1			0.971	24
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.948	16
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.943	22
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.883	10
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.823	17
UniProt:Q92843 B2CL2			0.77	7
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.758	6
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.659	4
UniProt:P17361 PG035			0.656	3
UniProt:P49334 TOM22	1	TOM22 [mitochondrial outer membrane] (R-SCE-1252087)	0.623	3
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957)	0.619	7
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.615	5
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.612	6
UniProt:P70444	4	Bid [mitochondrial outer membrane] (R-MMU-114266) Bid [cytosol] (R-MMU-141373) Bid [cytosol] (R-MMU-50825) Bid [cytosol] (R-MMU-139953)	0.609	2
UniProt:Q8IVG9 MT-RNR2	1	MT-RNR2 [extracellular region] (R-HSA-444568)	0.593	5
UniProt:P26662-PRO_0000037647			0.591	3
UniProt:Q9HD36 B2L10			0.564	3
UniProt:P16778 VGLI			0.558	2
UniProt:O75031 HSF2B			0.556	3
UniProt:Q7Z419 RNF144B	1	RNF144B [cytosol] (R-HSA-975988)	0.556	5
UniProt:Q9HB09 B2L12			0.547	3
UniProt:P70444-PRO_0000223236 BID			0.544	2
UniProt:Q9Y371-1 SH3GLB1			0.544	2
IntAct:EBI-4399559 UBIQ			0.524	2
UniProt:P07213 TOM70	1	TOM70 [mitochondrial outer membrane] (R-SCE-1252058)	0.499	2
UniProt:P23644 TOM40	4	TOM40 [mitochondrial intermembrane space] (R-SCE-1252162) TOM40 [mitochondrial intermembrane space] (R-SCE-1252037) TOM40 [cytosol] (R-SCE-1252146) TOM40 [mitochondrial outer membrane] (R-SCE-1252201)	0.499	2

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