Activation of BMF and translocation to mitochondria

Stable Identifier
R-HSA-139910
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of BMF and translocation to mitochondria
Click the image above or here to open this pathway in the Pathway Browser

In healthy cells, BMF is bound to the myosin V motor complex through its interaction with DLC2. UV irradiation or anoikis induces MAPK8 (JNK) to phosphorylate Dynein Light Chain 2 (DLC2) to release BMF.

Literature References
PubMed ID Title Journal Year
14634621 The Bcl-2 family: roles in cell survival and oncogenesis.

Cory, S, Huang, DC, Adams, JM

Oncogene 2003
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)
Orthologous Events
Activation of BMF and translocation to mitochondria (Bos taurus)
Activation of BMF and translocation to mitochondria (Canis familiaris)
Activation of BMF and translocation to mitochondria (Danio rerio)
Activation of BMF and translocation to mitochondria (Gallus gallus)
Activation of BMF and translocation to mitochondria (Mus musculus)
Activation of BMF and translocation to mitochondria (Rattus norvegicus)
Activation of BMF and translocation to mitochondria (Sus scrofa)
Activation of BMF and translocation to mitochondria (Xenopus tropicalis)
Authored
Gopinathrao, G  (2004-08-20)
Reviewed
Vaux, DL  (2020-11-17)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
Cite Us!