Activation of BMF and translocation to mitochondria

Stable Identifier
R-HSA-139910
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
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Activation of BMF and translocation to mitochondria
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In healthy cells, BMF is bound to the myosin V motor complex through its interaction with DLC2. UV irradiation or anoikis induces MAPK8 (JNK) to phosphorylate Dynein Light Chain 2 (DLC2) to release BMF.

Literature References
PubMed ID Title Journal Year
14634621 The Bcl-2 family: roles in cell survival and oncogenesis.

Adams, JM, Huang, DC, Cory, S

Oncogene 2003
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Events
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Event Information
Go Biological Process
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)
Orthologous Events
Activation of BMF and translocation to mitochondria (Bos taurus)
Activation of BMF and translocation to mitochondria (Canis familiaris)
Activation of BMF and translocation to mitochondria (Danio rerio)
Activation of BMF and translocation to mitochondria (Gallus gallus)
Activation of BMF and translocation to mitochondria (Mus musculus)
Activation of BMF and translocation to mitochondria (Rattus norvegicus)
Activation of BMF and translocation to mitochondria (Sus scrofa)
Authored
Gopinathrao, G  (2004-08-19)
Reviewed
Vaux, DL  (2022-03-10)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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