tBID activates BAK protein

Stable Identifier
R-HSA-139895
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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tBID binds to its mitochondrial partner BAK to release cytochrome c. It has been observed in mouse systems that the activated tBID results in an allosteric activation of BAK. Activated BAK induces intramembranous oligomerization leading to a pore for cytochrome c efflux (Wei et al. 2000).

Literature References
PubMed ID Title Journal Year
10950869 tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Wei, MC, Lindsten, T, Mootha, VK, Weiler, S, Gross, A, Ashiya, M, Thompson, CB, Korsmeyer, SJ

Genes Dev 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created