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IGF1 [platelet alpha granule lumen]
Stable Identifier
R-HSA-139878
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Insulin-like growth factor 1, Somatomedin C
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
Insulin-like growth factors [platelet alpha granule lumen] (Homo sapiens)
IGF1 [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05019 IGF1
Gene Names
IGF1, IBP1
Chain
signal peptide:1-21, propeptide:22-48, chain:49-118, propeptide:119-195
Reference Genes
BioGPS Gene:3479 IGF1
COSMIC (genes):IGF1 IGF1
CTD Gene:3479 IGF1
dbSNP Gene:3479 IGF1
ENSEMBL:ENSG00000017427 IGF1
HGNC:5464 IGF1
KEGG:hsa:3479 IGF1
Monarch:3479 IGF1
NCBI Gene:3479 IGF1
OMIM:147440 IGF1
UCSC:P05019 IGF1
Reference Transcript
RefSeq:NM_000618.4 IGF1
RefSeq:NM_001111284.1 IGF1
RefSeq:NM_001111285.2 IGF1
Other Identifiers
11729817_a_at
11729818_s_at
11729819_a_at
11743201_a_at
11743202_x_at
1501_at
1625_at
16769250
1975_s_at
209540_PM_at
209540_at
209541_PM_at
209541_at
209542_PM_x_at
209542_x_at
211577_PM_s_at
211577_s_at
3468346
3468347
3468348
3468350
3468351
3468352
3468353
3468354
3468372
3468377
3468378
3479
38737_at
64305_s_at
7965873
A_23_P13907
A_24_P304419
A_24_P304423
A_24_P398572
GE59822
GE80397
GO:0001501
GO:0001775
GO:0001837
GO:0001932
GO:0003012
GO:0005158
GO:0005159
GO:0005178
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0006355
GO:0007165
GO:0007265
GO:0007517
GO:0008083
GO:0008283
GO:0008284
GO:0009408
GO:0009441
GO:0010468
GO:0010560
GO:0010613
GO:0010628
GO:0010629
GO:0014834
GO:0014896
GO:0014904
GO:0014911
GO:0016942
GO:0030154
GO:0030166
GO:0030335
GO:0031093
GO:0031410
GO:0032148
GO:0032691
GO:0032720
GO:0034392
GO:0035630
GO:0035867
GO:0042060
GO:0042104
GO:0042531
GO:0042567
GO:0043066
GO:0043226
GO:0043388
GO:0043410
GO:0043568
GO:0045445
GO:0045669
GO:0045725
GO:0045821
GO:0045840
GO:0045893
GO:0045944
GO:0046326
GO:0046579
GO:0048009
GO:0048018
GO:0048146
GO:0048661
GO:0048856
GO:0050679
GO:0050714
GO:0050731
GO:0050821
GO:0051450
GO:0051897
GO:0060283
GO:0061051
GO:0070374
GO:0070382
GO:0070886
GO:0090201
GO:0098772
GO:0150079
GO:1901135
GO:1902430
GO:1904075
GO:1904646
GO:1904707
GO:1905460
GO:2000679
GO:2001237
HMNXSV003048040
HMNXSV003048731
Hs.85112.0.S2_3p_at
Hs.85112.0.S3_3p_at
ILMN_1709613
ILMN_2056087
PH_hs_0023679
TC12001890.hg
X57025_at
g184833_3p_a_at
Participates
as a member of
Insulin-like growth factors [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
IGF1 [extracellular region]
Inferred To
IGF1 [platelet alpha granule lumen]
(Bos taurus)
IGF1 [platelet alpha granule lumen]
(Canis familiaris)
IGF1 [platelet alpha granule lumen]
(Gallus gallus)
IGF1 [platelet alpha granule lumen]
(Sus scrofa)
Igf1 [platelet alpha granule lumen]
(Mus musculus)
Igf1 [platelet alpha granule lumen]
(Rattus norvegicus)
igf1 [platelet alpha granule lumen]
(Danio rerio)
igf1 [platelet alpha granule lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001104754.1
,
NP_001104755.1
,
NP_000609.1
OpenTargets
ENSG00000017427
ENSEMBL
ENST00000392905
,
ENST00000392904
,
ENSP00000416811
,
ENST00000337514
,
ENST00000644491
,
ENST00000424202
,
ENST00000307046
,
ENSP00000337612
,
ENSP00000376637
,
ENSP00000376638
,
ENSP00000302665
,
ENSP00000494228
HPA
ENSG00000017427-IGF1
PRO
P05019
Pharos - Targets
P05019
Orphanet
IGF1
PDB
1IMX
,
8EYR
,
6PYH
,
3LRI
,
1GZY
,
2DSQ
,
1GZZ
,
2DSR
,
1PMX
,
1GZR
,
2DSP
,
1TGR
,
2GF1
,
6FF3
,
7YRR
,
1H02
,
7WRQ
,
4XSS
,
6RVA
,
1BQT
,
5U8Q
,
3GF1
,
1H59
,
1B9G
,
7S0Q
,
1WQJ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08069 IGF1R
3
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
0.783
8
UniProt:P22692 IGFBP4
5
IGFBP4 [extracellular region]
(R-HSA-381421)
IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8956754)
p-IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8957038)
IGFBP4(157-237) [extracellular region]
(R-HSA-381510)
IGFBP4(22-156) [extracellular region]
(R-HSA-381516)
0.76
7
UniProt:P08833 IGFBP1
3
IGFBP1 [extracellular region]
(R-HSA-381513)
p-IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8957029)
IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8956699)
0.623
2
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