Reactome | IGF1 [platelet alpha granule lumen]

IGF1 [platelet alpha granule lumen]

Stable Identifier

R-HSA-139878

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Insulin-like growth factor 1, Somatomedin C

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
        
        Insulin-like growth factors [platelet alpha granule lumen] (Homo sapiens)
        
        IGF1 [platelet alpha granule lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05019 IGF1

Gene Names

IGF1, IBP1

Chain

signal peptide:1-21, propeptide:22-48, chain:49-118, propeptide:119-195

Reference Genes

BioGPS Gene:3479 IGF1

COSMIC (genes):IGF1 IGF1

CTD Gene:3479 IGF1

dbSNP Gene:3479 IGF1

ENSEMBL:ENSG00000017427 IGF1

HGNC:5464 IGF1

KEGG Gene (Homo sapiens):3479 IGF1

Monarch:3479 IGF1

NCBI Gene:3479 IGF1

OMIM:147440 IGF1

UCSC:P05019 IGF1

Reference Transcript

Other Identifiers

0006980373

11729817_a_at

11729818_s_at

11729819_a_at

11743201_a_at

11743202_x_at

1501_at

1625_at

16769250

1975_s_at

1B9G

1BQT

1GF1

1GZR

1GZY

1GZZ

1H02

1H59

1IMX

1PMX

1TGR

1WQJ

209540_at

209541_at

209542_x_at

211577_s_at

2DSP

2DSQ

2DSR

2GF1

3468346

3468347

3468348

3468351

3468352

3468353

3468354

3468372

3468377

3468378

3479

38737_at

3GF1

3LRI

48946

4XSS

5U8Q

64305_s_at

6FF3

7965873

A_23_P13907

A_24_P304419

A_24_P304423

A_24_P398572

AAA52537

AAA52538

AAA52539

AAA52787

AAA52789

AAI48267

AAI52322

AAO74829

AAV40833

AC010202

AC068648

AY260957

AY790940

BC148266

BC152321

CAA24998

CAA27152

CAA27153

CAA27154

CAA27250

CAA40092

CAA40093

CAA40342

CCDS44960

CCDS44961

CCDS9091

CH471054

EAW97696

EAW97697

EAW97698

ENSG00000017427

ENSP00000302665

ENSP00000337612

ENSP00000376637

ENSP00000376638

ENSP00000416811

ENSP00000494228

ENST00000307046

ENST00000307046.8

ENST00000337514

ENST00000337514.10

ENST00000392904

ENST00000392904.5

ENST00000392905

ENST00000392905.7

ENST00000424202

ENST00000424202.6

ENST00000644491

ENST00000644491.1

EntrezGene:3479

EntrezGene:IGF1

g184833_3p_a_at

GE59822

GE80397

GO:0000003

GO:0000187

GO:0000278

GO:0001501

GO:0001775

GO:0002376

GO:0002576

GO:0003674

GO:0005158

GO:0005159

GO:0005178

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005886

GO:0005975

GO:0006091

GO:0006464

GO:0006810

GO:0006950

GO:0007005

GO:0007049

GO:0007155

GO:0007165

GO:0007265

GO:0007517

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009408

GO:0009441

GO:0009790

GO:0010468

GO:0010560

GO:0010613

GO:0010628

GO:0010629

GO:0014065

GO:0014068

GO:0014834

GO:0014896

GO:0014904

GO:0014911

GO:0015031

GO:0016192

GO:0016942

GO:0021700

GO:0030154

GO:0030166

GO:0030335

GO:0031093

GO:0031410

GO:0032148

GO:0032691

GO:0032720

GO:0032991

GO:0034392

GO:0034641

GO:0035630

GO:0035867

GO:0040007

GO:0040011

GO:0040014

GO:0042104

GO:0042531

GO:0042567

GO:0043066

GO:0043226

GO:0043388

GO:0043410

GO:0043491

GO:0043568

GO:0044267

GO:0044281

GO:0045445

GO:0045669

GO:0045725

GO:0045821

GO:0045840

GO:0045893

GO:0045944

GO:0046326

GO:0046579

GO:0048009

GO:0048015

GO:0048146

GO:0048661

GO:0048856

GO:0048870

GO:0050679

GO:0050714

GO:0050731

GO:0050821

GO:0051450

GO:0055085

GO:0060283

GO:0061051

GO:0070371

GO:0070382

GO:0070886

GO:0090201

GO:0140014

GO:0150079

GO:1902430

GO:1904075

GO:1904646

GO:1904707

GO:1905460

GO:2000679

GO:2001237

HGNC:5464

HPA048946

Hs.85112.0.S2_3p_at

Hs.85112.0.S3_3p_at

IGF1

IGF1-201

IGF1-202

IGF1-203

IGF1-204

IGF1-205

IGF1-207

ILMN_1709613

ILMN_2056087

IPR016179

IPR022341

IPR022350

IPR022352

IPR022353

IPR036438

M11568

M12659

M14153

M14154

M14155

M14156

M27544

M37484

MIM:147440

MIM:608747

NM_000618

NM_001111283

NM_001111284

NM_001111285

NP_000609

NP_001104753

NP_001104754

NP_001104755

PF00049

PH_hs_0023679

PR00276

PR02002

PR02005

Q13429

Q5U743

SM00078

TC12001890.hg

UPI0000048D6E

UPI000006E89E

UPI0000115ED4

UPI000155D519

X00173

X03420

X03421

X03422

X03563

X56773

X56774

X57025

X57025_at

XM_017019262

XM_017019263

XP_016874751

XP_016874752

Participant Of

hasMember

Insulin-like growth factors [platelet alpha granule lumen]

Other forms of this molecule

IGF1 [extracellular region]

Inferred To

IGF1 [platelet alpha granule lumen] (Bos taurus)

IGF1 [platelet alpha granule lumen] (Canis familiaris)

IGF1 [platelet alpha granule lumen] (Gallus gallus)

IGF1 [platelet alpha granule lumen] (Sus scrofa)

Igf1 [platelet alpha granule lumen] (Mus musculus)

Igf1 [platelet alpha granule lumen] (Rattus norvegicus)

igf1 [platelet alpha granule lumen] (Danio rerio)

igf1 [platelet alpha granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001104755.1, NP_001104754.1, NP_000609.1

OpenTargets

ENSG00000017427

HPA

ENSG00000017427-IGF1

GeneCards

P05019

Ensembl

ENSP00000376638, ENSP00000302665, ENST00000392904, ENST00000392905, ENSP00000376637, ENST00000337514, ENSP00000416811, ENSG00000017427, ENST00000307046, ENSP00000494228, ENSP00000337612, ENST00000644491, ENST00000424202

PRO

P05019

Orphanet

16245

PDB

1IMX, 3LRI, 6RVA, 2DSP, 6PYH, 2DSR, 1BQT, 2DSQ, 1GZZ, 1B9G, 1GF1, 1PMX, 6FF3, 1GZY, 1H59, 4XSS, 1TGR, 1H02, 5U8Q, 1GZR, 1WQJ, 2GF1, 3GF1

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.783	8
UniProt:P22692 IGFBP4	5	IGFBP4(157-237) [extracellular region] (R-HSA-381510) IGFBP4(22-156) [extracellular region] (R-HSA-381516) IGFBP4 [extracellular region] (R-HSA-381421) p-IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8957038) IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8956754)	0.76	7
UniProt:P08833 IGFBP1	3	p-IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8957029) IGFBP1 [extracellular region] (R-HSA-381513) IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8956699)	0.623	2

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