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IGF1
Stable Identifier
R-HSA-139878
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Insulin-like growth factor 1, Somatomedin C
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
Insulin-like growth factors [platelet alpha granule lumen] (Homo sapiens)
IGF1 [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05019 IGF1
Gene Names
IGF1, IBP1
Chain
signal peptide:1-21, propeptide:22-48, chain:49-118, propeptide:119-195
Reference Genes
BioGPS Gene:3479 IGF1
COSMIC (genes):IGF1 IGF1
CTD Gene:3479 IGF1
dbSNP Gene:3479 IGF1
ENSEMBL:ENSG00000017427 IGF1
HGNC:5464 IGF1
KEGG Gene (Homo sapiens):hsa:3479 IGF1
Monarch:3479 IGF1
NCBI Gene:3479 IGF1
OMIM:147440 IGF1
UCSC:P05019 IGF1
Reference Transcript
RefSeq:NM_001111285.2 IGF1
RefSeq:NM_001111284.1 IGF1
RefSeq:NM_000618.4 IGF1
Other Identifiers
0006980373
11729817_a_at
11729818_s_at
11729819_a_at
11743201_a_at
11743202_x_at
1501_at
1625_at
16769250
1975_s_at
1B9G
1BQT
1GF1
1GZR
1GZY
1GZZ
1H02
1H59
1IMX
1PMX
1TGR
1WQJ
209540_at
209541_at
209542_x_at
211577_s_at
2DSP
2DSQ
2DSR
2GF1
3468347
3468348
3468351
3468352
3468353
3468354
3468372
3468377
3468378
3479
38737_at
3GF1
3LRI
48946
4XSS
64305_s_at
7965873
A_23_P13907
A_24_P304419
A_24_P304423
A_24_P398572
AAA52537
AAA52538
AAA52539
AAA52787
AAA52789
AAI48267
AAI52322
AAO74829
AAV40833
CAA24998
CAA27152
CAA27153
CAA27154
CAA27250
CAA40092
CAA40093
CAA40342
CCDS44960
CCDS44961
CCDS9091
EAW97696
EAW97697
EAW97698
ENSG00000017427
ENSP00000302665
ENSP00000337612
ENSP00000376637
ENSP00000394999
ENSP00000416811
ENST00000307046
ENST00000337514
ENST00000392904
ENST00000424202
ENST00000456098
EntrezGene:3479
g184833_3p_a_at
GE59822
GE80397
GO:0000187
GO:0001501
GO:0001775
GO:0002576
GO:0005158
GO:0005159
GO:0005178
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006260
GO:0006928
GO:0007165
GO:0007265
GO:0007517
GO:0008083
GO:0008283
GO:0008284
GO:0009408
GO:0009441
GO:0010468
GO:0010469
GO:0010560
GO:0010613
GO:0010628
GO:0014065
GO:0014068
GO:0014834
GO:0014896
GO:0014904
GO:0014911
GO:0016942
GO:0030166
GO:0030335
GO:0031093
GO:0032148
GO:0033160
GO:0034392
GO:0035630
GO:0035867
GO:0040014
GO:0042104
GO:0042531
GO:0042567
GO:0043066
GO:0043388
GO:0043410
GO:0043491
GO:0043568
GO:0044267
GO:0045445
GO:0045669
GO:0045725
GO:0045740
GO:0045821
GO:0045840
GO:0045893
GO:0045944
GO:0046326
GO:0046579
GO:0048009
GO:0048015
GO:0048146
GO:0048661
GO:0050679
GO:0050714
GO:0050731
GO:0050821
GO:0051450
GO:0060283
GO:0061051
GO:0070371
GO:0070382
GO:0070886
GO:0090201
GO:1904075
GO:1904646
GO:2000679
GO:2001237
HGNC:5464
HPA048946
Hs.85112.0.S2_3p_at
Hs.85112.0.S3_3p_at
IGF1
IGF1-201
IGF1-202
IGF1-203
IGF1-205
IGF1-206
ILMN_1709613
ILMN_2056087
IPR016179
IPR022341
IPR022350
IPR022352
IPR022353
MIM:147440
MIM:608747
NM_000618
NM_001111283
NM_001111284
NM_001111285
NP_000609
NP_001104753
NP_001104754
NP_001104755
PF00049
PH_hs_0023679
PR00276
PR02002
PR02005
Q13429
Q5U743
SM00078
TC12001890.hg
uc001tjm.2
uc001tjn.3
uc001tjo.3
uc001tjp.5
uc058skd.1
UPI0000048D6E
UPI000006E89E
UPI0000115ED4
UPI000155D519
X57025_at
XM_017019260
XM_017019262
XM_017019263
XP_016874749
XP_016874751
XP_016874752
Participant Of
hasMember
Insulin-like growth factors [platelet alpha granule lumen]
Other forms of this molecule
IGF1 [extracellular region]
IGF1 [extracellular region]
Inferred To
IGF1 [platelet alpha granule lumen] (Bos taurus)
IGF1 [platelet alpha granule lumen] (Canis familiaris)
IGF1 [platelet alpha granule lumen] (Danio rerio)
IGF1 [platelet alpha granule lumen] (Gallus gallus)
IGF1 [platelet alpha granule lumen] (Mus musculus)
IGF1 [platelet alpha granule lumen] (Rattus norvegicus)
IGF1 [platelet alpha granule lumen] (Sus scrofa)
IGF1 [platelet alpha granule lumen] (Taeniopygia guttata)
IGF1 [platelet alpha granule lumen] (Xenopus tropicalis)
Cross References
RefSeq
NP_001104755.1
,
NP_001104754.1
,
NP_000609.1
Brenda
2.7.10.1
GeneCards
P05019
DOCK Blaster
1GZR
,
1IMX
,
1TGR
,
2DSR
,
2DSQ
,
1H02
,
1H59
,
2DSP
,
4XSS
,
1GZZ
,
1GZY
,
1WQJ
PRO
P05019
Orphanet
16245
PDB
1WQJ
,
1GF1
,
1TGR
,
1BQT
,
1PMX
,
4XSS
,
3LRI
,
1B9G
,
1IMX
,
1H59
,
3GF1
,
2GF1
,
1H02
,
2DSR
,
1GZZ
,
1GZY
,
2DSQ
,
2DSP
,
1GZR
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08069 IGF1R
3
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.783
8
UniProt:P22692 IGFBP4
5
IGFBP4(157-237) [extracellular region]
(R-HSA-381510)
IGFBP4(22-156) [extracellular region]
(R-HSA-381516)
IGFBP4 [extracellular region]
(R-HSA-381421)
p-IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8957038)
IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8956754)
0.76
7
UniProt:P08833 IGFBP1
3
p-IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8957029)
IGFBP1 [extracellular region]
(R-HSA-381513)
IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8956699)
0.623
2
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