PRLR binds SHP2 (PTPN11)

Stable Identifier
R-HSA-1369114
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tyrosine-phosphorylated PRLR can bind the protein-tyrosine Phosphatase SHP2 (PTPN11) via its C-terminal SH2 Domain. This binding does not occur when the most C-terminal PRLR tyrosine residue (residue 611 in the human canonical Uniprot sequence, equivalent to 587 in the mature protein with signal peptide removed) is mutated to alanine (Ali & Ali 2000).

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